PDB entry 3k4s

View 3k4s on RCSB PDB site
Description: The structure of the catalytic domain of human PDE4d with 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone
Class: hydrolase
Keywords: nucleotide binding, phosphodiesterase, Alternative splicing, cAMP, Cytoplasm, Cytoskeleton, Hydrolase, Membrane, Metal-binding, Phosphoprotein
Deposited on 2009-10-06, released 2009-10-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-10-20, with a file datestamp of 2009-10-16.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.211
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4D, DPDE3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08499 (21-End)
      • expression tag (19-20)
    Domains in SCOPe 2.08: d3k4sa1, d3k4sa2
  • Heterogens: ZN, 0MO, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3k4sA (A:)
mgsshhhhhhssglvprgshmteqedvlakeledvnkwglhvfriaelsgnrpltvimht
ifqerdllktfkipvdtlitylmtledhyhadvayhnnihaadvvqsthvllstpaleav
ftdleilaaifasaihdvdhpgvsnqflintnselalmyndssvlenhhlavgfkllqee
ncdifqnltkkqrqslrkmvidivlatdmskhmnlladlktmvetkkvtssgvllldnys
driqvlqnmvhcadlsnptkplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnas
veksqvgfidyivhplwetwadlvhpdaqdildtlednrewyqstipqs

    Sequence, based on observed residues (ATOM records): (download) 
    >3k4sA (A:)
hmteqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtli
tylmtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvd
hpgvsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkm
vidivlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnpt
kplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwet
wadlvhpdaqdildtlednrewyqstipq