PDB entry 3jwr

View 3jwr on RCSB PDB site
Description: Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.
Class: hydrolase
Keywords: mostly alpha, cGMP, Hydrolase, Polymorphism, Sensory transduction, Vision
Deposited on 2009-09-18, released 2009-10-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 2.99 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O76074 (4-255)
      • expression tag (1-3)
    • Uniprot P51160 (256-295)
    • Uniprot O76074 (296-End)
    Domains in SCOPe 2.08: d3jwrb1, d3jwrb2
  • Chain 'C':
    Compound: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN, MG, IBM, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3jwrB (B:)
    gshmeetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqm
    khevlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaa
    lshdldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeyk
    ttlkiikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitk
    pwpiqqriaelvatefweqgdlertvlqqqpipmmdrnkrdelpklqvgfidfvctqlye
    althvsedcfplldgcrknrqkwqalaeqq
    

    Sequence, based on observed residues (ATOM records): (download)
    >3jwrB (B:)
    shmeetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmk
    hevlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaal
    shdldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykt
    tlkiikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkp
    wpiqqriaelvatefweqgdlertvlqqqpipmmdrnkrdelpklqvgfidfvctqlyea
    lthvsedcfplldgcrknrqkwqalaeq
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.