PDB entry 3jwr
View 3jwr on RCSB PDB site
Description: Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87.
Class: hydrolase
Keywords: mostly alpha, cGMP, Hydrolase, Polymorphism, Sensory transduction, Vision
Deposited on
2009-09-18, released
2009-10-13
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-01, with a file datestamp of
2017-10-27.
Experiment type: XRAY
Resolution: 2.99 Å
R-factor: N/A
AEROSPACI score: 0.13
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3jwrb1, d3jwrb2 - Chain 'C':
Compound: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Heterogens: ZN, MG, IBM, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3jwrB (B:)
gshmeetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqm
khevlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaa
lshdldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeyk
ttlkiikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitk
pwpiqqriaelvatefweqgdlertvlqqqpipmmdrnkrdelpklqvgfidfvctqlye
althvsedcfplldgcrknrqkwqalaeqq
Sequence, based on observed residues (ATOM records): (download)
>3jwrB (B:)
shmeetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmk
hevlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaal
shdldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykt
tlkiikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkp
wpiqqriaelvatefweqgdlertvlqqqpipmmdrnkrdelpklqvgfidfvctqlyea
lthvsedcfplldgcrknrqkwqalaeq
- Chain 'C':
No sequence available.
- Chain 'D':
No sequence available.