PDB entry 3jw0

View 3jw0 on RCSB PDB site
Description: E2~Ubiquitin-HECT
Class: ligase/signaling protein
Keywords: Ubiquitin, HECT, E3, Ubiquitin ligase, UbcH5B, NEDD4L, NEDD4-2, Ligase, Ubl conjugation pathway, Isopeptide bond, Nucleus, Host-virus interaction, LIGASE-SIGNALING PROTEIN complex
Deposited on 2009-09-17, released 2010-01-12
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-03-21, with a file datestamp of 2012-03-16.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.252
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ubiquitin-conjugating enzyme e2 d2
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2D2, UBC4, UBCH5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62837 (0-145)
      • engineered (1)
      • engineered (83)
      • engineered (96)
    Domains in SCOPe 2.06: d3jw0a_
  • Chain 'B':
    Compound: ubiquitin-conjugating enzyme e2 d2
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2D2, UBC4, UBCH5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62837 (0-145)
      • engineered (1)
      • engineered (83)
      • engineered (96)
    Domains in SCOPe 2.06: d3jw0b_
  • Chain 'C':
    Compound: E3 ubiquitin-protein ligase NEDD4-like
    Species: Homo sapiens [TaxId:9606]
    Gene: NEDD4L, KIAA0439, NEDL3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96PU5 (5-End)
      • expression tag (4)
      • engineered (351)
    Domains in SCOPe 2.06: d3jw0c1, d3jw0c2
  • Chain 'D':
    Compound: E3 ubiquitin-protein ligase NEDD4-like
    Species: Homo sapiens [TaxId:9606]
    Gene: NEDD4L, KIAA0439, NEDL3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96PU5 (5-End)
      • engineered (351)
    Domains in SCOPe 2.06: d3jw0d_
  • Chain 'X':
    Compound: Ubiquitin
    Species: Homo sapiens [TaxId:9606]
    Gene: RPS27A, UBA80, UBCEP1, UBA52, UBCEP2, UBB, UBC
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3jw0x_
  • Chain 'Y':
    Compound: Ubiquitin
    Species: Homo sapiens [TaxId:9606]
    Gene: RPS27A, UBA80, UBCEP1, UBA52, UBCEP2, UBB, UBC
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3jw0y_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3jw0A (A:)
    askrihkelndlardppaqcsagpvgddmfhwqatimgpndspyqggvffltihfptdyp
    fkppkvafttriyhpninsngsisldilrsqwspalkiskvllsicsllcdpnpddplvp
    eiariyktdrekynriarewtqkyam
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3jw0B (B:)
    askrihkelndlardppaqcsagpvgddmfhwqatimgpndspyqggvffltihfptdyp
    fkppkvafttriyhpninsngsisldilrsqwspalkiskvllsicsllcdpnpddplvp
    eiariyktdrekynriarewtqkyam
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3jw0C (C:)
    gspefefkqkydyfrkklkkpadipnrfemklhrnnifeesyrrimsvkrpdvlkarlwi
    efesekgldyggvarewffllskemfnpyyglfeysatdnytlqinpnsglcnedhlsyf
    tfigrvaglavfhgklldgffirpfykmmlgkqitlndmesvdseyynslkwilendpte
    ldlmfcideenfgqtyqvdlkpngseimvtnenkreyidlviqwrfvnrvqkqmnafleg
    ftellpidlikifdenelellmcglgdvdvndwrqhsiykngycpnhpviqwfwkavllm
    daekrirllqfvtgtsrvpmngfaelygsngpqlftieqwgspeklprahtsfnrldlpp
    yetfedlrekllmavenaqgfegvd
    

    Sequence, based on observed residues (ATOM records): (download)
    >3jw0C (C:)
    fefkqkydyfrkklkkpadipnrfemklhrnnifeesyrrimsvkrpdvlkarlwiefes
    ekgldyggvarewffllskemfnpyyglfeysatdnytlqinpnsglcnedhlsyftfig
    rvaglavfhgklldgffirpfykmmlgkqitlndmesvdseyynslkwilendpteldlm
    fcideenfgqtyqvdlkpngseimvtnenkreyidlviqwrfvnrvqkqmnaflegftel
    lpidlikifdenelellmcglgdvdvndwrqhsiykngycpnhpviqwfwkavllmdaek
    rirllqfvtgtsrvpmngfaelygsngpqlftieqwgspeklprahtsfnrldlppyetf
    edlrekllmavenaqg
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >3jw0D (D:)
    gspefefkqkydyfrkklkkpadipnrfemklhrnnifeesyrrimsvkrpdvlkarlwi
    efesekgldyggvarewffllskemfnpyyglfeysatdnytlqinpnsglcnedhlsyf
    tfigrvaglavfhgklldgffirpfykmmlgkqitlndmesvdseyynslkwilendpte
    ldlmfcideenfgqtyqvdlkpngseimvtnenkreyidlviqwrfvnrvqkqmnafleg
    ftellpidlikifdenelellmcglgdvdvndwrqhsiykngycpnhpviqwfwkavllm
    daekrirllqfvtgtsrvpmngfaelygsngpqlftieqwgspeklprahtsfnrldlpp
    yetfedlrekllmavenaqgfegvd
    

    Sequence, based on observed residues (ATOM records): (download)
    >3jw0D (D:)
    efkqkydyfrkklkkpadipnrfemklhrnnifeesyrrimsvkrpdvlkarlwiefese
    kgldyggvarewffllskemfnpyyglfeysatdnytlqinpnsglcnedhlsyftfigr
    vaglavfhgklldgffirpfykmmlgkqitlndmesvdseyynslkwilendpteldlmf
    cideenfgqtyqvdlkpngseimvtnenkreyidlviqwrfvnrvqkqmnaflegftell
    pidlikifdenelellmcglgdvdvndwrqhsiykngycpnhpviqwfwkavllmdaekr
    irllqfvtgtsrvpmngfaelygsngpqlftieqwgspeklprahtsfnrldlppyetfe
    dlrekllmavenaq
    

  • Chain 'X':
    Sequence, based on SEQRES records: (download)
    >3jw0X (X:)
    gsggsmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrt
    lsdyniqkestlhlvlrlrgg
    

    Sequence, based on observed residues (ATOM records): (download)
    >3jw0X (X:)
    mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
    iqkestlhlvlrlrgg
    

  • Chain 'Y':
    Sequence, based on SEQRES records: (download)
    >3jw0Y (Y:)
    gsggsmqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrt
    lsdyniqkestlhlvlrlrgg
    

    Sequence, based on observed residues (ATOM records): (download)
    >3jw0Y (Y:)
    mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
    iqkestlhlvlrlrgg