PDB entry 3js2

View 3js2 on RCSB PDB site
Description: Crystal structure of minimal kinase domain of fibroblast growth factor receptor 1 in complex with 5-(2-thienyl)nicotinic acid
Class: transferase
Keywords: fibroblast growth factor, receptor tyrosine kinase, inhibitor, thienyl nicotinic acid, Alternative splicing, ATP-binding, Chromosomal rearrangement, Craniosynostosis, Disease mutation, Disulfide bond, Dwarfism, Glycoprotein, Heparin-binding, Hypogonadotropic hypogonadism, Immunoglobulin domain, Kallmann syndrome, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Receptor, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2009-09-09, released 2010-02-23
The last revision prior to the SCOPe 2.03 freeze date was dated 2010-03-02, with a file datestamp of 2010-02-26.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.216
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Basic fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, FGFBR, FLG, FLT2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362 (Start-316)
      • engineered (39)
    Domains in SCOPe 2.03: d3js2a_
  • Chain 'B':
    Compound: Basic fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, FGFBR, FLG, FLT2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • engineered (39)
    Domains in SCOPe 2.03: d3js2b_
  • Heterogens: VM1, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3js2A (A:)
    mghhhhhhmagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrv
    tkvavkmlksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgn
    lreylqarrppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarn
    vlvtednvmkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgv
    llweiftlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfk
    qlvedldrivaltsnqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >3js2A (A:)
    elpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdatek
    dlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppglhn
    peeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglardihh
    idyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelf
    kllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnqe
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3js2B (B:)
    mghhhhhhmagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrv
    tkvavkmlksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgn
    lreylqarrppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarn
    vlvtednvmkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgv
    llweiftlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfk
    qlvedldrivaltsnqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >3js2B (B:)
    gvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlks
    datekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrp
    peqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglardihhi
    dyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfk
    llkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivalts