PDB entry 3is4

View 3is4 on RCSB PDB site
Description: Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK)in complex with 1,3,6,8-pyrenetetrasulfonic acid
Class: transferase
Keywords: TRANSFERASE, Allosteric enzyme, ATP-binding, Glycolysis, Kinase, Magnesium, Metal-binding, Nucleotide-binding, Pyruvate
Deposited on 2009-08-25, released 2010-03-23
The last revision prior to the SCOPe 2.06 freeze date was dated 2010-03-23, with a file datestamp of 2010-03-19.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.232
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: pyruvate kinase
    Species: Leishmania mexicana [TaxId:5665]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q27686 (Start-498)
      • see remark 999 (382)
      • see remark 999 (389)
      • see remark 999 (404-405)
    Domains in SCOPe 2.06: d3is4a1, d3is4a2, d3is4a3
  • Chain 'B':
    Compound: pyruvate kinase
    Species: Leishmania mexicana [TaxId:5665]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q27686 (Start-498)
      • see remark 999 (382)
      • see remark 999 (389)
      • see remark 999 (404-405)
    Domains in SCOPe 2.06: d3is4b1, d3is4b2, d3is4b3
  • Heterogens: GOL, PTK, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3is4A (A:)
msqlahnltlsifdpvanyraariictigpstqsvealkgliqsgmsvarmnfshgshey
hqttinnvrqaaaelgvniaialdtkgpeirtgqfvggdavmergatcyvttdpafadkg
tkdkfyidyqnlskvvrpgnyiyiddgililqvqshedeqtlectvtnshtisdrrgvnl
pgcdvdlpavsakdrvdlqfgveqgvdmifasfirsaeqvgdvrkalgpkgrdimiicki
enhqgvqnidsiieesdgimvargdlgveipaekvvvaqkiliskcnvagkpvicatqml
esmtynprptraevsdvanavfngadcvmlsgetakgkypnevvqymaricleaqsalne
yvffnsikklqhipmsadeavcssavnsvyetkakamvvlsntgrsarlvakyrpncpiv
cvttrlqtcrqlnitqgvesvffdadklghdegkehrvaagvefakskgyvqtgdycvvi
hadhkvkgyanqtrillve

    Sequence, based on observed residues (ATOM records): (download) 
    >3is4A (A:)
sqlahnltlsifdpvanyraariictigpstqsvealkgliqsgmsvarmnfshgsheyh
qttinnvrqaaaelgvniaialdtkgpeirtgqfvggdavmergatcyvttdpafadkgt
kdkfyidyqnlskvvrpgnyiyiddgililqvqshedeqtlectvtnshtisdrrgvnlp
gcdvdlpavsakdrvdlqfgveqgvdmifasfirsaeqvgdvrkalgpkgrdimiickie
nhqgvqnidsiieesdgimvargdlgveipaekvvvaqkiliskcnvagkpvicatqmle
smtynprptraevsdvanavfngadcvmlsgetakgkypnevvqymaricleaqsalney
vffnsikklqhipmsadeavcssavnsvyetkakamvvlsntgrsarlvakyrpncpivc
vttrlqtcrqlnitqgvesvffdadklghdegkehrvaagvefakskgyvqtgdycvvih
ayanqtrillve

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3is4B (B:)
msqlahnltlsifdpvanyraariictigpstqsvealkgliqsgmsvarmnfshgshey
hqttinnvrqaaaelgvniaialdtkgpeirtgqfvggdavmergatcyvttdpafadkg
tkdkfyidyqnlskvvrpgnyiyiddgililqvqshedeqtlectvtnshtisdrrgvnl
pgcdvdlpavsakdrvdlqfgveqgvdmifasfirsaeqvgdvrkalgpkgrdimiicki
enhqgvqnidsiieesdgimvargdlgveipaekvvvaqkiliskcnvagkpvicatqml
esmtynprptraevsdvanavfngadcvmlsgetakgkypnevvqymaricleaqsalne
yvffnsikklqhipmsadeavcssavnsvyetkakamvvlsntgrsarlvakyrpncpiv
cvttrlqtcrqlnitqgvesvffdadklghdegkehrvaagvefakskgyvqtgdycvvi
hadhkvkgyanqtrillve

    Sequence, based on observed residues (ATOM records): (download) 
    >3is4B (B:)
sqlahnltlsifdpvanyraariictigpstqsvealkgliqsgmsvarmnfshgsheyh
qttinnvrqaaaelgvniaialdtkgpeirtgqfvggdavmergatcyvttdpafadkgt
kdkfyidyqnlskvvrpgnyiyiddgililqvqshedeqtlectvtnshtisdrrgvnlp
gcdvdlpavsakdrvdlqfgveqgvdmifasfirsaeqvgdvrkalgpkgrdimiickie
nhqgvqnidsiieesdgimvargdlgveipaekvvvaqkiliskcnvagkpvicatqmle
smtynprptraevsdvanavfngadcvmlsgetakgkypnevvqymaricleaqsalney
vffnsikklqhipmsadeavcssavnsvyetkakamvvlsntgrsarlvakyrpncpivc
vttrlqtcrqlnitqgvesvffdadklghdegkehrvaagvefakskgyvqtgdycvvih
ayanqtrillve