PDB entry 3iph

View 3iph on RCSB PDB site
Description: Crystal structure of p38 in complex with a biphenylamide inhibitor
Class: transferase
Keywords: P38, SERINE/THREONINE PROTEIN KINASE, MAP KINASE, ATP-binding, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Deposited on 2009-08-17, released 2009-11-24
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.184
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 14
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3ipha_
  • Heterogens: G11, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3iphA (A:)
msqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfq
siihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcq
kltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemt
gyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvg
tpgaellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaa
qalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppldqeemes

    Sequence, based on observed residues (ATOM records): (download) 
    >3iphA (A:)
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglhtddemtgyvat
rwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgae
llkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalah
ayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp