PDB entry 3iop

View 3iop on RCSB PDB site
Description: PDK-1 in complex with the inhibitor Compound-8i
Class: transferase
Keywords: PDK-1, inhibitor, Alternative splicing, ATP-binding, Cytoplasm, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Deposited on 2009-08-14, released 2010-02-16
The last revision prior to the SCOPe 2.03 freeze date was dated 2010-03-23, with a file datestamp of 2010-03-19.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.24
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-phosphoinositide-dependent protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PDPK1, PDK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3iopa_
  • Heterogens: 8I1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3iopA (A:)
gpamdgtaaeprpgagslqhaqpppqprkkrpedfkfgkilgegsfstvvlarelatsre
yaikilekrhiikenkvpyvtrerdvmsrldhpffvklyftfqddeklyfglsyakngel
lkyirkigsfdetctrfytaeivsaleylhgkgiihrdlkpenillnedmhiqitdfgta
kvlspeskqaransfvgtaqyvspellteksackssdlwalgciiyqlvaglppfragne
ylifqkiikleydfpekffpkardlvekllvldatkrlgceemegygplkahpffesvtw
enlhqqtppklt

    Sequence, based on observed residues (ATOM records): (download) 
    >3iopA (A:)
rkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvm
srldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsale
ylhgkgiihrdlkpenillnedmhiqitdfgtakvlssfvgtaqyvspellteksackss
dlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvldatk
rlgceemegygplkahpffesvtwenlhqqtppklt