PDB entry 3iok

View 3iok on RCSB PDB site
Description: 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2
Class: transferase
Keywords: kinase, inhibitor, jak2, janus kinase, ATP-binding, Disease mutation, Membrane, Nucleotide-binding, Phosphoprotein, Proto-oncogene, SH2 domain, Transferase, Tyrosine-protein kinase
Deposited on 2009-08-14, released 2009-11-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-04-03, with a file datestamp of 2013-03-29.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.228
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3ioka_
  • Heterogens: 1P6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3iokA (A:)
mgsshhhhhhssglvprgshnmtqfeerhlkflqqlgkgnfgsvemcrydplqdntgevv
avkklqhsteehlrdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrd
ylqkhkeridhikllqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltk
vlpqdkeyykvkepgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppa
efmrmigndkqgqmivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdl
alrvdqirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >3iokA (A:)
tqfeerhlkflqqlgkggsvemcrydplqdntgevvavkklqhsteehlrdfereieilk
slqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqickg
meylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyap
eslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellk
nngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnm