PDB entry 3im6

View 3im6 on RCSB PDB site
Description: Crystal structure of mouse Ryanodine Receptor 2 mutant V186M
Class: signaling protein
Keywords: ryanodine receptor 2, calcium release channel, ion channel, arrhythmia, CPVT, ARVD2, ARVC2, disease mutation, Ion transport, Ionic channel, Transmembrane, Transport
Deposited on 2009-08-09, released 2009-11-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-12-01, with a file datestamp of 2009-11-27.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.203
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cardiac Ca2+ release channel
    Species: Mus musculus [TaxId:10090]
    Gene: Ryr2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9ERN6 (Start-216)
      • engineered (185)
    Domains in SCOPe 2.08: d3im6a_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3im6A (A:)
madagegedeiqflrtddevvlqctatihkeqqklclaaegfgnrlcflestsnsknvpp
dlsictfvleqslsvralqemlantveksegqvdvekwkfmmktaqggghrtllyghail
lrhsysgmylcclstsrsstdklafdvglqedttgeacwwtihpaskqrsegekvrvgdd
lilvsmsserylhlsygnsswhvdaafqqtlwsvapi

    Sequence, based on observed residues (ATOM records): (download) 
    >3im6A (A:)
qflrtddevvlqctatihkeqqklclaaegfgnrlcflestsvppdlsictfvleqslsv
ralqemlantvewhrtllyghaillrhsysgmylcclstslafdvglqedttgeacwwti
hpaskqrsegekvrvgddlilvsmsserylhlsygnsswhvdaafqqtlwsvapi