PDB entry 3ik3
View 3ik3 on RCSB PDB site
Description: AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance
Class: transferase
Keywords: Bcr-Abl, CML, T315I, inhibitor, mutation, drug resistance, Alternative splicing, ATP-binding, Cell adhesion, Chromosomal rearrangement, Cytoplasm, Cytoskeleton, Kinase, Lipoprotein, Magnesium, Manganese, Metal-binding, Myristate, Nucleotide-binding, Nucleus, Phosphoprotein, Proto-oncogene, SH2 domain, SH3 domain, Transferase
Deposited on
2009-08-05, released
2009-11-03
The last revision prior to the SCOPe 2.01 freeze date was dated
2010-04-28, with a file datestamp of
2010-04-23.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.216
AEROSPACI score: 0.45
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proto-oncogene tyrosine-protein kinase ABL1
Species: Mus musculus [TaxId:10090]
Gene: Abl1, Abl
Database cross-references and differences (RAF-indexed):
- Uniprot P00520 (1-285)
- expression tag (0)
- engineered (87)
Domains in SCOPe 2.01: d3ik3a_ - Chain 'B':
Compound: Proto-oncogene tyrosine-protein kinase ABL1
Species: Mus musculus [TaxId:10090]
Gene: Abl1, Abl
Database cross-references and differences (RAF-indexed):
- Uniprot P00520 (1-285)
- expression tag (0)
- engineered (87)
Domains in SCOPe 2.01: d3ik3b_ - Heterogens: 0LI, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3ik3A (A:)
gspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
avmkeikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevsavvllymatqi
ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
vyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelgkrgt
Sequence, based on observed residues (ATOM records): (download)
>3ik3A (A:)
gspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
avmkeikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevsavvllymatqi
ssameylekknfihrdlaarnclvgenhlvkvadfglstytahagakfpikwtapeslay
nkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmr
acwqwnpsdrpsfaeihqafetmfqessisdevekelgkr
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3ik3B (B:)
gspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
avmkeikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevsavvllymatqi
ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
vyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelgkrgt
Sequence, based on observed residues (ATOM records): (download)
>3ik3B (B:)
gspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
avmkeikhpnlvqllgvctreppfyiiiefmtygnlldylrecnrqevsavvllymatqi
ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
vyelmracwqwnpsdrpsfaeihqafetmfqessisdevekelgkr