PDB entry 3ii0

View 3ii0 on RCSB PDB site
Description: Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1)
Class: transferase
Keywords: Glutamate oxaloacetate transaminase 1, aspartate aminotransferase 1, pyridoxal phosphate-dependent enzyme, amino acid metabolism, urea and tricarboxylic acid cycles, Structural Genomics, Structural Genomics Consortium, SGC, Aminotransferase, Phosphoprotein, Pyridoxal phosphate, Transferase
Deposited on 2009-07-31, released 2009-08-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aspartate aminotransferase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: GOT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17174 (Start-399)
      • expression tag (400-406)
    Domains in SCOPe 2.07: d3ii0a1, d3ii0a2
  • Chain 'B':
    Compound: Aspartate aminotransferase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: GOT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17174 (Start-399)
      • expression tag (400-406)
    Domains in SCOPe 2.07: d3ii0b1, d3ii0b2
  • Chain 'C':
    Compound: Aspartate aminotransferase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: GOT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17174 (1-399)
      • expression tag (0)
      • expression tag (400-406)
    Domains in SCOPe 2.07: d3ii0c1, d3ii0c2, d3ii0c3
  • Chain 'D':
    Compound: Aspartate aminotransferase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: GOT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P17174 (1-399)
      • expression tag (0)
      • expression tag (400-406)
    Domains in SCOPe 2.07: d3ii0d1, d3ii0d2, d3ii0d3
  • Heterogens: PLP, TAR, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ii0A (A:)
mqpvlvfkltadfredpdprkvnlgvgayrtddchpwvlpvvkkveqkiandnslnheyl
pilglaefrscasrlalgddspalkekrvggvqslggtgalrigadflarwyngtnnknt
pvyvssptwenhnavfsaagfkdirsyrywdaekrgldlqgflndlenapefsivvlhac
ahnptgidptpeqwkqiasvmkhrflfpffdsayqgfasgnlerdawairyfvsegfeff
caqsfsknfglynervgnltvvgkepesilqvlsqmekivritwsnppaqgarivastls
npelfeewtgnvktmadriltmrselrarlealktpgtwnhitdqigmfsftglnpkqve
ylvnekhiyllpsgrinvsglttknldyvatsiheavtkiaenlyfqshhhhhhdykddd
dk

    Sequence, based on observed residues (ATOM records): (download) 
    >3ii0A (A:)
pvlvfkltadfredpdprkvnlgvgayrtddchpwvlpvvkkveqkiandnslnheylpi
lglaefrscasrlalgddspalkekrvggvqslggtgalrigadflarwyngtnnkntpv
yvssptwenhnavfsaagfkdirsyrywdaekrgldlqgflndlenapefsivvlhacah
nptgidptpeqwkqiasvmkhrflfpffdsayqgfasgnlerdawairyfvsegfeffca
qsfsknfglynervgnltvvgkepesilqvlsqmekivritwsnppaqgarivastlsnp
elfeewtgnvktmadriltmrselrarlealktpgtwnhitdqigmfsftglnpkqveyl
vnekhiyllpsgrinvsglttknldyvatsiheavtkiaenlyfq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ii0B (B:)
mqpvlvfkltadfredpdprkvnlgvgayrtddchpwvlpvvkkveqkiandnslnheyl
pilglaefrscasrlalgddspalkekrvggvqslggtgalrigadflarwyngtnnknt
pvyvssptwenhnavfsaagfkdirsyrywdaekrgldlqgflndlenapefsivvlhac
ahnptgidptpeqwkqiasvmkhrflfpffdsayqgfasgnlerdawairyfvsegfeff
caqsfsknfglynervgnltvvgkepesilqvlsqmekivritwsnppaqgarivastls
npelfeewtgnvktmadriltmrselrarlealktpgtwnhitdqigmfsftglnpkqve
ylvnekhiyllpsgrinvsglttknldyvatsiheavtkiaenlyfqshhhhhhdykddd
dk

    Sequence, based on observed residues (ATOM records): (download) 
    >3ii0B (B:)
pvlvfkltadfredpdprkvnlgvgayrtddchpwvlpvvkkveqkiandnslnheylpi
lglaefrscasrlalgddspalkekrvggvqslggtgalrigadflarwyngtnnkntpv
yvssptwenhnavfsaagfkdirsyrywdaekrgldlqgflndlenapefsivvlhacah
nptgidptpeqwkqiasvmkhrflfpffdsayqgfasgnlerdawairyfvsegfeffca
qsfsknfglynervgnltvvgkepesilqvlsqmekivritwsnppaqgarivastlsnp
elfeewtgnvktmadriltmrselrarlealktpgtwnhitdqigmfsftglnpkqveyl
vnekhiyllpsgrinvsglttknldyvatsiheavtkiaenlyfq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3ii0C (C:)
mqpvlvfkltadfredpdprkvnlgvgayrtddchpwvlpvvkkveqkiandnslnheyl
pilglaefrscasrlalgddspalkekrvggvqslggtgalrigadflarwyngtnnknt
pvyvssptwenhnavfsaagfkdirsyrywdaekrgldlqgflndlenapefsivvlhac
ahnptgidptpeqwkqiasvmkhrflfpffdsayqgfasgnlerdawairyfvsegfeff
caqsfsknfglynervgnltvvgkepesilqvlsqmekivritwsnppaqgarivastls
npelfeewtgnvktmadriltmrselrarlealktpgtwnhitdqigmfsftglnpkqve
ylvnekhiyllpsgrinvsglttknldyvatsiheavtkiaenlyfqshhhhhhdykddd
dk

    Sequence, based on observed residues (ATOM records): (download) 
    >3ii0C (C:)
mqpvlvfkltadfredpdprkvnlgvgayrtddchpwvlpvvkkveqkiandnslnheyl
pilglaefrscasrlalgddspalkekrvggvqslggtgalrigadflarwyngtnnknt
pvyvssptwenhnavfsaagfkdirsyrywdaekrgldlqgflndlenapefsivvlhac
ahnptgidptpeqwkqiasvmkhrflfpffdsayqgfasgnlerdawairyfvsegfeff
caqsfsknfglynervgnltvvgkepesilqvlsqmekivritwsnppaqgarivastls
npelfeewtgnvktmadriltmrselrarlealktpgtwnhitdqigmfsftglnpkqve
ylvnekhiyllpsgrinvsglttknldyvatsiheavtkiaenlyfq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3ii0D (D:)
mqpvlvfkltadfredpdprkvnlgvgayrtddchpwvlpvvkkveqkiandnslnheyl
pilglaefrscasrlalgddspalkekrvggvqslggtgalrigadflarwyngtnnknt
pvyvssptwenhnavfsaagfkdirsyrywdaekrgldlqgflndlenapefsivvlhac
ahnptgidptpeqwkqiasvmkhrflfpffdsayqgfasgnlerdawairyfvsegfeff
caqsfsknfglynervgnltvvgkepesilqvlsqmekivritwsnppaqgarivastls
npelfeewtgnvktmadriltmrselrarlealktpgtwnhitdqigmfsftglnpkqve
ylvnekhiyllpsgrinvsglttknldyvatsiheavtkiaenlyfqshhhhhhdykddd
dk

    Sequence, based on observed residues (ATOM records): (download) 
    >3ii0D (D:)
mqpvlvfkltadfredpdprkvnlgvgayrtddchpwvlpvvkkveqkiandnslnheyl
pilglaefrscasrlalgddspalkekrvggvqslggtgalrigadflarwyngtnnknt
pvyvssptwenhnavfsaagfkdirsyrywdaekrgldlqgflndlenapefsivvlhac
ahnptgidptpeqwkqiasvmkhrflfpffdsayqgfasgnlerdawairyfvsegfeff
caqsfsknfglynervgnltvvgkepesilqvlsqmekivritwsnppaqgarivastls
npelfeewtgnvktmadriltmrselrarlealktpgtwnhitdqigmfsftglnpkqve
ylvnekhiyllpsgrinvsglttknldyvatsiheavtkiaenlyfq