PDB entry 3iei

View 3iei on RCSB PDB site
Description: Crystal structure of human leucine carboxylmethyltransferase-1 in complex with S-adenosyl homocysteine
Class: transferase
Keywords: LCMT-1, Methyltransferase, S-adenosyl-L-methionine, Transferase
Deposited on 2009-07-22, released 2010-08-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-08-11, with a file datestamp of 2010-08-06.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.186
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Leucine carboxyl methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CGI-68, LCMT, LCMT-1, LCMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIC8 (Start-333)
      • engineered (114)
    Domains in SCOPe 2.08: d3ieia_
  • Chain 'B':
    Compound: Leucine carboxyl methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CGI-68, LCMT, LCMT-1, LCMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIC8 (Start-333)
      • engineered (114)
    Domains in SCOPe 2.08: d3ieib_
  • Chain 'C':
    Compound: Leucine carboxyl methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CGI-68, LCMT, LCMT-1, LCMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIC8 (Start-333)
      • engineered (114)
    Domains in SCOPe 2.08: d3ieic_
  • Chain 'D':
    Compound: Leucine carboxyl methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CGI-68, LCMT, LCMT-1, LCMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIC8 (Start-333)
      • engineered (114)
    Domains in SCOPe 2.08: d3ieid_
  • Chain 'E':
    Compound: Leucine carboxyl methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CGI-68, LCMT, LCMT-1, LCMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIC8 (Start-333)
      • engineered (114)
    Domains in SCOPe 2.08: d3ieie_
  • Chain 'F':
    Compound: Leucine carboxyl methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CGI-68, LCMT, LCMT-1, LCMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIC8 (Start-333)
      • engineered (114)
    Domains in SCOPe 2.08: d3ieif_
  • Chain 'G':
    Compound: Leucine carboxyl methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CGI-68, LCMT, LCMT-1, LCMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIC8 (Start-333)
      • engineered (114)
    Domains in SCOPe 2.08: d3ieig_
  • Chain 'H':
    Compound: Leucine carboxyl methyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CGI-68, LCMT, LCMT-1, LCMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UIC8 (Start-333)
      • engineered (114)
    Domains in SCOPe 2.08: d3ieih_
  • Heterogens: SAH, GOL, MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ieiA (A:)
matrqressitsccstssmdendegvrgtcedaslckrfavsigywhdpyiqhfvrlske
rkapeinrgyfarvhgvsqlikaflrktechcqivnlgagmdttfwrlkdedllsskyfe
vdfpmivtrklhsikckpplsspilelhsedtlqmdghildskryavigadlrdlselee
klkkcnmntqlptlliaecvlvymtpeqsanllkwaansferamfinyeqvnmgdrfgqi
mienlrrrqcdlagvetckslesqkerllsngwetasavdmmelynrlpraevsriesle
fldemelleqlmrhyclcwatkggnelglkeity

    Sequence, based on observed residues (ATOM records): (download) 
    >3ieiA (A:)
gvrgtcedaslckrfavsigywhdpyiqhfvrlskerkapeinrgyfarvhgvsqlikaf
lrktechcqivnlgagmdttfwrlkdedllsskyfevdfpmivtrklhsikckpplsspi
lelhsedtlqmdghildskryavigadlrdlseleeklkkcnmntqlptlliaecvlvym
tpeqsanllkwaansferamfinyeqvnmgdrfgqimienlrrrqcdlagvetckslesq
kerllsngwetasavdmmelynrlpraevsrieslefldemelleqlmrhyclcwatkgg
nelglkeity

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ieiB (B:)
matrqressitsccstssmdendegvrgtcedaslckrfavsigywhdpyiqhfvrlske
rkapeinrgyfarvhgvsqlikaflrktechcqivnlgagmdttfwrlkdedllsskyfe
vdfpmivtrklhsikckpplsspilelhsedtlqmdghildskryavigadlrdlselee
klkkcnmntqlptlliaecvlvymtpeqsanllkwaansferamfinyeqvnmgdrfgqi
mienlrrrqcdlagvetckslesqkerllsngwetasavdmmelynrlpraevsriesle
fldemelleqlmrhyclcwatkggnelglkeity

    Sequence, based on observed residues (ATOM records): (download) 
    >3ieiB (B:)
gvrgtcedaslckrfavsigywhdpyiqhfvrlskerkapeinrgyfarvhgvsqlikaf
lrktechcqivnlgagmdttfwrlkdedllsskyfevdfpmivtrklhsikckpplsspi
lelhsedtlqmdghildskryavigadlrdlseleeklkkcnmntqlptlliaecvlvym
tpeqsanllkwaansferamfinyeqvnmgdrfgqimienlrrrqcdlagvetckslesq
kerllsngwetasavdmmelynrlpraevsrieslefldemelleqlmrhyclcwatkgg
nelglkeity

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3ieiC (C:)
matrqressitsccstssmdendegvrgtcedaslckrfavsigywhdpyiqhfvrlske
rkapeinrgyfarvhgvsqlikaflrktechcqivnlgagmdttfwrlkdedllsskyfe
vdfpmivtrklhsikckpplsspilelhsedtlqmdghildskryavigadlrdlselee
klkkcnmntqlptlliaecvlvymtpeqsanllkwaansferamfinyeqvnmgdrfgqi
mienlrrrqcdlagvetckslesqkerllsngwetasavdmmelynrlpraevsriesle
fldemelleqlmrhyclcwatkggnelglkeity

    Sequence, based on observed residues (ATOM records): (download) 
    >3ieiC (C:)
gvrgtcedaslckrfavsigywhdpyiqhfvrlskerkapeinrgyfarvhgvsqlikaf
lrktechcqivnlgagmdttfwrlkdedllsskyfevdfpmivtrklhsikckpplsspi
lelhsedtlqmdghildskryavigadlrdlseleeklkkcnmntqlptlliaecvlvym
tpeqsanllkwaansferamfinyeqvnmgdrfgqimienlrrrqcdlagvetckslesq
kerllsngwetasavdmmelynrlpraevsrieslefldemelleqlmrhyclcwatkgg
nelglkeity

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3ieiD (D:)
matrqressitsccstssmdendegvrgtcedaslckrfavsigywhdpyiqhfvrlske
rkapeinrgyfarvhgvsqlikaflrktechcqivnlgagmdttfwrlkdedllsskyfe
vdfpmivtrklhsikckpplsspilelhsedtlqmdghildskryavigadlrdlselee
klkkcnmntqlptlliaecvlvymtpeqsanllkwaansferamfinyeqvnmgdrfgqi
mienlrrrqcdlagvetckslesqkerllsngwetasavdmmelynrlpraevsriesle
fldemelleqlmrhyclcwatkggnelglkeity

    Sequence, based on observed residues (ATOM records): (download) 
    >3ieiD (D:)
gvrgtcedaslckrfavsigywhdpyiqhfvrlskerkapeinrgyfarvhgvsqlikaf
lrktechcqivnlgagmdttfwrlkdedllsskyfevdfpmivtrklhsikckpplsspi
lelhsedtlqmdghildskryavigadlrdlseleeklkkcnmntqlptlliaecvlvym
tpeqsanllkwaansferamfinyeqvnmgdrfgqimienlrrrqcdlagvetckslesq
kerllsngwetasavdmmelynrlpraevsrieslefldemelleqlmrhyclcwatkgg
nelglkeity

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3ieiE (E:)
matrqressitsccstssmdendegvrgtcedaslckrfavsigywhdpyiqhfvrlske
rkapeinrgyfarvhgvsqlikaflrktechcqivnlgagmdttfwrlkdedllsskyfe
vdfpmivtrklhsikckpplsspilelhsedtlqmdghildskryavigadlrdlselee
klkkcnmntqlptlliaecvlvymtpeqsanllkwaansferamfinyeqvnmgdrfgqi
mienlrrrqcdlagvetckslesqkerllsngwetasavdmmelynrlpraevsriesle
fldemelleqlmrhyclcwatkggnelglkeity

    Sequence, based on observed residues (ATOM records): (download) 
    >3ieiE (E:)
gvrgtcedaslckrfavsigywhdpyiqhfvrlskerkapeinrgyfarvhgvsqlikaf
lrktechcqivnlgagmdttfwrlkdedllsskyfevdfpmivtrklhsikckpplsspi
lelhsedtlqmdghildskryavigadlrdlseleeklkkcnmntqlptlliaecvlvym
tpeqsanllkwaansferamfinyeqvnmgdrfgqimienlrrrqcdlagvetckslesq
kerllsngwetasavdmmelynrlpraevsrieslefldemelleqlmrhyclcwatkgg
nelglkeity

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3ieiF (F:)
matrqressitsccstssmdendegvrgtcedaslckrfavsigywhdpyiqhfvrlske
rkapeinrgyfarvhgvsqlikaflrktechcqivnlgagmdttfwrlkdedllsskyfe
vdfpmivtrklhsikckpplsspilelhsedtlqmdghildskryavigadlrdlselee
klkkcnmntqlptlliaecvlvymtpeqsanllkwaansferamfinyeqvnmgdrfgqi
mienlrrrqcdlagvetckslesqkerllsngwetasavdmmelynrlpraevsriesle
fldemelleqlmrhyclcwatkggnelglkeity

    Sequence, based on observed residues (ATOM records): (download) 
    >3ieiF (F:)
gvrgtcedaslckrfavsigywhdpyiqhfvrlskerkapeinrgyfarvhgvsqlikaf
lrktechcqivnlgagmdttfwrlkdedllsskyfevdfpmivtrklhsikckpplsspi
lelhsedtlqmdghildskryavigadlrdlseleeklkkcnmntqlptlliaecvlvym
tpeqsanllkwaansferamfinyeqvnmgdrfgqimienlrrrqcdlagvetckslesq
kerllsngwetasavdmmelynrlpraevsrieslefldemelleqlmrhyclcwatkgg
nelglkeity

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3ieiG (G:)
matrqressitsccstssmdendegvrgtcedaslckrfavsigywhdpyiqhfvrlske
rkapeinrgyfarvhgvsqlikaflrktechcqivnlgagmdttfwrlkdedllsskyfe
vdfpmivtrklhsikckpplsspilelhsedtlqmdghildskryavigadlrdlselee
klkkcnmntqlptlliaecvlvymtpeqsanllkwaansferamfinyeqvnmgdrfgqi
mienlrrrqcdlagvetckslesqkerllsngwetasavdmmelynrlpraevsriesle
fldemelleqlmrhyclcwatkggnelglkeity

    Sequence, based on observed residues (ATOM records): (download) 
    >3ieiG (G:)
gvrgtcedaslckrfavsigywhdpyiqhfvrlskerkapeinrgyfarvhgvsqlikaf
lrktechcqivnlgagmdttfwrlkdedllsskyfevdfpmivtrklhsikckpplsspi
lelhsedtlqmdghildskryavigadlrdlseleeklkkcnmntqlptlliaecvlvym
tpeqsanllkwaansferamfinyeqvnmgdrfgqimienlrrrqcdlagvetckslesq
kerllsngwetasavdmmelynrlpraevsrieslefldemelleqlmrhyclcwatkgg
nelglkeity

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >3ieiH (H:)
matrqressitsccstssmdendegvrgtcedaslckrfavsigywhdpyiqhfvrlske
rkapeinrgyfarvhgvsqlikaflrktechcqivnlgagmdttfwrlkdedllsskyfe
vdfpmivtrklhsikckpplsspilelhsedtlqmdghildskryavigadlrdlselee
klkkcnmntqlptlliaecvlvymtpeqsanllkwaansferamfinyeqvnmgdrfgqi
mienlrrrqcdlagvetckslesqkerllsngwetasavdmmelynrlpraevsriesle
fldemelleqlmrhyclcwatkggnelglkeity

    Sequence, based on observed residues (ATOM records): (download) 
    >3ieiH (H:)
gvrgtcedaslckrfavsigywhdpyiqhfvrlskerkapeinrgyfarvhgvsqlikaf
lrktechcqivnlgagmdttfwrlkdedllsskyfevdfpmivtrklhsikckpplsspi
lelhsedtlqmdghildskryavigadlrdlseleeklkkcnmntqlptlliaecvlvym
tpeqsanllkwaansferamfinyeqvnmgdrfgqimienlrrrqcdlagvetckslesq
kerllsngwetasavdmmelynrlpraevsrieslefldemelleqlmrhyclcwatkgg
nelglkeity