PDB entry 3i4b

View 3i4b on RCSB PDB site
Description: Crystal structure of GSK3b in complex with a pyrimidylpyrrole inhibitor
Class: transferase
Keywords: kinase, gsk3b, ERK, Pyrimidyl pyrrole, Alternative splicing, ATP-binding, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Wnt signaling pathway
Deposited on 2009-07-01, released 2010-01-12
The last revision prior to the SCOPe 2.03 freeze date was dated 2010-01-12, with a file datestamp of 2010-01-08.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.181
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glycogen synthase kinase-3 beta
    Species: Homo sapiens [TaxId:9606]
    Gene: GSK3B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3i4ba_
  • Chain 'B':
    Compound: Glycogen synthase kinase-3 beta
    Species: Homo sapiens [TaxId:9606]
    Gene: GSK3B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3i4bb_
  • Heterogens: Z48, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3i4bA (A:)
    ttsfaesckpvqqpsafgsmkvsrdkdgskvttvvatpgqgpdrpqevsytdtkvigngs
    fgvvyqaklcdsgelvaikkvlqdkrfknrelqimrkldhcnivrlryffyssgekkdev
    ylnlvldyvpetvyrvarhysrakqtlpviyvklymyqlfrslayihsfgichrdikpqn
    llldpdtavlklcdfgsakqlvrgepnvsyicsryyrapelifgatdytssidvwsagcv
    laelllgqpifpgdsgvdqlveiikvlgtptreqiremnpnytefkfpqikahpwtkvfr
    prtppeaialcsrlleytptarltpleacahsffdelrdpnvklpngrdtpalfnfttqe
    lssnpplatilipphariqaaastptnataasdantgdrgqtnnaasasasnst
    

    Sequence, based on observed residues (ATOM records): (download)
    >3i4bA (A:)
    smkvsrdgskvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikk
    vlqdkrfknrelqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhy
    srakqtlpviyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakq
    lvrgepnvsyicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdql
    veiikvlgtptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytpt
    arltpleacahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphariq
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3i4bB (B:)
    ttsfaesckpvqqpsafgsmkvsrdkdgskvttvvatpgqgpdrpqevsytdtkvigngs
    fgvvyqaklcdsgelvaikkvlqdkrfknrelqimrkldhcnivrlryffyssgekkdev
    ylnlvldyvpetvyrvarhysrakqtlpviyvklymyqlfrslayihsfgichrdikpqn
    llldpdtavlklcdfgsakqlvrgepnvsyicsryyrapelifgatdytssidvwsagcv
    laelllgqpifpgdsgvdqlveiikvlgtptreqiremnpnytefkfpqikahpwtkvfr
    prtppeaialcsrlleytptarltpleacahsffdelrdpnvklpngrdtpalfnfttqe
    lssnpplatilipphariqaaastptnataasdantgdrgqtnnaasasasnst
    

    Sequence, based on observed residues (ATOM records): (download)
    >3i4bB (B:)
    kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfkn
    relqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpv
    iyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvs
    yicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgt
    ptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleac
    ahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilippha