PDB entry 3hyg
View 3hyg on RCSB PDB site
Description: Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound
Class: hydrolase
Keywords: alpha/beta structure, central five stranded beta-sheet, Cleavage on pair of basic residues, Disulfide bond, Extracellular matrix, Glycoprotein, Hydrolase, Metal-binding, Metalloprotease, Polymorphism, Protease, Secreted, Zinc, Zymogen
Deposited on
2009-06-22, released
2009-07-07
The last revision prior to the SCOPe 2.03 freeze date was dated
2009-09-15, with a file datestamp of
2009-09-11.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: 0.182
AEROSPACI score: 0.68
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: A disintegrin and metalloproteinase with thrombospondin motifs 5
Species: Homo sapiens [TaxId:9606]
Gene: ADAMTS-5, ADAMTS11, ADAMTS5, ADMP2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d3hyga_ - Chain 'B':
Compound: A disintegrin and metalloproteinase with thrombospondin motifs 5
Species: Homo sapiens [TaxId:9606]
Gene: ADAMTS-5, ADAMTS11, ADAMTS5, ADMP2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d3hygb_ - Heterogens: ZN, CA, 099, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3hygA (A:)
masisrarqvelllvadasmarkygrglqhylltlasianrlyshasienhirlavvkvv
vlgdkdkslevsknaattlknfckwqhqhnqlgddheehydaailftredlcghhscdtl
gmadvgticsperscavieddglhaaftvaheighllglshddskfceetfgstedkrlm
ssiltsidaskpwskctsatiteflddghgnclldlprkqi
Sequence, based on observed residues (ATOM records): (download)
>3hygA (A:)
srarqvelllvadasmarkygrglqhylltlasianrlyshasienhirlavvkvvvlgd
kdkslevsknaattlknfckwqhqhnqlgddheehydaailftredlcghhscdtlgmad
vgticsperscavieddglhaaftvaheighllglshddskfceetfgstedkrlmssil
tsidaskpwskctsatiteflddghgnclldlprkqi
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3hygB (B:)
masisrarqvelllvadasmarkygrglqhylltlasianrlyshasienhirlavvkvv
vlgdkdkslevsknaattlknfckwqhqhnqlgddheehydaailftredlcghhscdtl
gmadvgticsperscavieddglhaaftvaheighllglshddskfceetfgstedkrlm
ssiltsidaskpwskctsatiteflddghgnclldlprkqi
Sequence, based on observed residues (ATOM records): (download)
>3hygB (B:)
srarqvelllvadasmarkygrglqhylltlasianrlyshasienhirlavvkvvvlgd
kdkslevsknaattlknfckwqhqhnqlgddheehydaailftredlcghhscdtlgmad
vgticsperscavieddglhaaftvaheighllglshddskfceetfgstedkrlmssil
tsidaskpwskctsatiteflddghgnclldlprkqi