PDB entry 3hxo

View 3hxo on RCSB PDB site
Description: Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding
Class: blood clotting/blood clotting regulator
Keywords: ARC1779, VWF, Platelet Glycoprotein Ib, Aptamer, ARC1772, Blood coagulation, Cell adhesion, Cleavage on pair of basic residues, Disease mutation, Disulfide bond, Extracellular matrix, Glycoprotein, Hemostasis, Isopeptide bond, Secreted, von Willebrand disease, BLOOD CLOTTING-BLOOD CLOTTING REGULATOR COMPLEX
Deposited on 2009-06-21, released 2009-11-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-26, with a file datestamp of 2020-02-21.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: von willebrand factor
  Species: Homo sapiens [TaxId:9606]
  Gene: VWF, F8VWF
  Database cross-references and differences (RAF-indexed):
  • Uniprot P04275 (Start-208)
  Domains in SCOPe 2.08: d3hxoa_
• Chain 'B':
  Compound: Aptamer ARC1172
  Species: synthetic, synthetic
  
• Heterogens: HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >3hxoA (A:)
  edisepplhdfycsrlldlvflldgssrlseaefevlkafvvdmmerlrisqkwvrvavv
  eyhdgshayiglkdrkrpselrriasqvkyagsqvastsevlkytlfqifskidrpeasr
  ialllmasqepqrmsrnfvryvqglkkkkvivipvgigphanlkqirliekqapenkafv
  lssvdeleqqrdeivsylcdlapeapppt
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3hxoA (A:)
  fycsrlldlvflldgssrlseaefevlkafvvdmmerlrisqkwvrvavveyhdgshayi
  glkdrkrpselrriasqvkyagsqvastsevlkytlfqifskidrpeasrialllmasqe
  pqrmsrnfvryvqglkkkkvivipvgigphanlkqirliekqapenkafvlssvdeleqq
  rdeivsylcdlapeapppt
  

  
  
• Chain 'B':
  No sequence available.