PDB entry 3hrc

View 3hrc on RCSB PDB site
Description: Crystal structure of a mutant of human PDK1 Kinase domain in complex with ATP
Class: transferase
Keywords: AGC Kinase, PHOSPHORYLATION, ALLOSTERY, PDK1, ACTIVATION LOOP, ATP BINDING, ATP-binding, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Deposited on 2009-06-09, released 2009-09-15
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-11-13, with a file datestamp of 2013-11-08.
Experiment type: XRAY
Resolution: 1.91 Å
R-factor: 0.182
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-phosphoinositide-dependent protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK1, PDPK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15530 (Start-310)
      • engineered (239)
      • engineered (243)
    Domains in SCOPe 2.06: d3hrca_
  • Heterogens: ATP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3hrcA (A:)
gamdgtaaeprpgagslqhaqpppqprkkrpedfkfgkilgegsfstvvlarelatsrey
aikilekrhiikenkvpyvtrerdvmsrldhpffvklyftfqddeklyfglsyakngell
kyirkigsfdetctrfytaeivsaleylhgkgiihrdlkpenillnedmhiqitdfgtak
vlspeskqaransfvgtaqyvspellteksackssdlwalgciiyqlvaglppfragneg
lifakiikleydfpekffpkardlvekllvldatkrlgceemegygplkahpffesvtwe
nlhqqtppklt

    Sequence, based on observed residues (ATOM records): (download) 
    >3hrcA (A:)
kkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvms
rldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsaley
lhgkgiihrdlkpenillnedmhiqitdfgtakvlsparansfvgtaqyvspellteksa
ckssdlwalgciiyqlvaglppfragneglifakiikleydfpekffpkardlvekllvl
datkrlgceemegygplkahpffesvtwenlhqqtppklt