PDB entry 3hqw

View 3hqw on RCSB PDB site
Description: Discovery of novel inhibitors of PDE10A
Class: hydrolase/hydrolase inhibitor
Keywords: Phosphodiesterase 10A PDE10A PDE inhibitors, Allosteric enzyme, Alternative splicing, cAMP, cAMP-binding, cGMP, cGMP-binding, Cytoplasm, Hydrolase, Magnesium, Metal-binding, Nucleotide-binding, Zinc, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Deposited on 2009-06-08, released 2009-08-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-04, with a file datestamp of 2018-03-29.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Species: Rattus norvegicus [TaxId:10116]
    Gene: PDE10A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3hqwa_
  • Heterogens: ZN, MG, PF4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3hqwA (A:)
mhhhhhhssglvprmhhhhhhssglvprgsamgtseewqglmhfnlparicrdielfhfd
igpfenmwpgifvymihrscgtscfeleklcrfimsvkknyrrvpyhnwkhavtvahcmy
ailqnnnglftdlerkglliaclchdldhrgfsnsylqkfdhplaalyststmeqhhfsq
tvsilqleghnifstlssseyeqvleiirkaiiatdlalyfgnrkqleemyqtgslnlhn
qshrdrviglmmtacdlcsvtklwpvtkltandiyaefwaegdemkklgiqpipmmdrdk
rdevpqgqlgfynavaipcyttltqilpptepllkacrdnlnqwekvirgeetamwisgp
atskstsekptrkvdd

    Sequence, based on observed residues (ATOM records): (download) 
    >3hqwA (A:)
paricrdielfhfdigpfenmwpgifvymihrscgtscfeleklcrfimsvkknyrrvpy
hnwkhavtvahcmyailqnnnglftdlerkglliaclchdldhrgfsnsylqkfdhplaa
lyststmeqhhfsqtvsilqleghnifstlssseyeqvleiirkaiiatdlalyfgnrkq
leemyqtgslnlhnqshrdrviglmmtacdlcsvtklwpvtkltandiyaefwaegdemk
klgiqpipmmdrdkrdevpqgqlgfynavaipcyttltqilpptepllkacrdnlnqwek
vir