PDB entry 3hpt

View 3hpt on RCSB PDB site
Description: Crystal structure of human FxA in complex with (S)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)guanidine
Class: hydrolase, blood clotting
Keywords: SERINE PROTEASE, HYDROLASE, EPIDERMAL GROWTH FACTOR LIKE DOMAIN, BLOOD COAGULATION FACTOR, CLEAVAGE ON PAIR OF BASIC RESIDUES, EGF-LIKE DOMAIN, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HYDROXYLATION, ZYMOGEN, BLOOD CLOTTING, Blood coagulation, Disulfide bond, Protease, Secreted
Deposited on 2009-06-04, released 2009-11-17
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.19 Å
R-factor: 0.179
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: coagulation factor x
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3hpta1, d3hpta2
  • Chain 'B':
    Compound: coagulation factor x
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3hptb_
  • Chain 'C':
    Compound: coagulation factor x
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3hptc1, d3hptc2
  • Chain 'D':
    Compound: coagulation factor x
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3hptd_
  • Heterogens: GOL, YET, CA, NA, MES, ACT, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3hptA (A:)
kdgdqcetspcqnqgkckdglgeytctclegfegkncelftrklcsldngdcdqfcheeq
nsvvcscargytladngkaciptgpypcgkqtle

    Sequence, based on observed residues (ATOM records): (download) 
    >3hptA (A:)
cspcqnqgkckdeytctclegfegkncelftrklcsldngdcdqfcheeqnsvvcscarg
ytladngkaciptgpypcgkqtle

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3hptB (B:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3hptC (C:)
kdgdqcetspcqnqgkckdglgeytctclegfegkncelftrklcsldngdcdqfcheeq
nsvvcscargytladngkaciptgpypcgkqtle

    Sequence, based on observed residues (ATOM records): (download) 
    >3hptC (C:)
qcespcqnqgkckdgeytctclegfegkncelftrklcsldngdcdqfcheeqnsvvcsc
argytladngkaciptgpypcgkqtle

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3hptD (D:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglp

    Sequence, based on observed residues (ATOM records): (download) 
    >3hptD (D:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthegrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqedac
qgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglp