PDB entry 3hoc

View 3hoc on RCSB PDB site
Description: Structure of the actin-binding domain of human filamin A mutant E254K
Class: Structural Protein
Keywords: Calponin homology domain, actin binding domain, Acetylation, Actin-binding, Alternative splicing, Cytoplasm, Cytoskeleton, Disease mutation, Phosphoprotein, Polymorphism, Structural Protein
Deposited on 2009-06-02, released 2009-10-13
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-12-01, with a file datestamp of 2009-11-27.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.224
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Filamin-A
    Species: Homo sapiens [TaxId:9606]
    Gene: FLNA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21333
      • engineered (256)
    Domains in SCOPe 2.05: d3hoca1, d3hoca2
  • Chain 'B':
    Compound: Filamin-A
    Species: Homo sapiens [TaxId:9606]
    Gene: FLNA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21333 (Start-271)
      • engineered (256)
    Domains in SCOPe 2.05: d3hocb1, d3hocb2
  • Heterogens: PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3hocA (A:)
    gamassshsragqsaagaapgggvdtrdaempatekdlaedapwkkiqqntftrwcnehl
    kcvskrianlqtdlsdglrliallevlsqkkmhrkhnqrptfrqmqlenvsvalefldre
    siklvsidskaivdgnlklilgliwtlilhysismpmwdeeedeeakkqtpkqrllgwiq
    nklpqlpitnfsrdwqsgralgalvdscapglcpdwdswdaskpvtnareamqqaddwlg
    ipqvitpeeivdpnvdkhsvmtylsqfpkakl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3hocA (A:)
    apwkkiqqntftrwcnehlkcvskrianlqtdlsdglrliallevlsqkkmhrkhnqrpt
    frqmqlenvsvalefldresiklvsidskaivdgnlklilgliwtlilhysismpqtpkq
    rllgwiqnklpqlpitnfsrdwqsgralgalvdscapglcpdwdswdaskpvtnareamq
    qaddwlgipqvitpeeivdpnvdkhsvmtylsqfp
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3hocB (B:)
    gamassshsragqsaagaapgggvdtrdaempatekdlaedapwkkiqqntftrwcnehl
    kcvskrianlqtdlsdglrliallevlsqkkmhrkhnqrptfrqmqlenvsvalefldre
    siklvsidskaivdgnlklilgliwtlilhysismpmwdeeedeeakkqtpkqrllgwiq
    nklpqlpitnfsrdwqsgralgalvdscapglcpdwdswdaskpvtnareamqqaddwlg
    ipqvitpeeivdpnvdkhsvmtylsqfpkakl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3hocB (B:)
    kkiqqntftrwcnehlkcvskrianlqtdlsdglrliallevlsqkkmhrkhnqrptfrq
    mqlenvsvalefldresiklvsidskaivdgnlklilgliwtlilhysismpmqtpkqrl
    lgwiqnklpqlpitnfsrdwqsgralgalvdscapglcpdwdswdaskpvtnareamqqa
    ddwlgipqvitpeeivdpnvdkhsvmtylsqfpkakl