PDB entry 3hm8

View 3hm8 on RCSB PDB site
Description: Crystal structure of the C-terminal Hexokinase domain of human HK3
Class: transferase
Keywords: glucose, glucose-6-phosphate, non-protein kinase, hexokinase, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, SGC, Allosteric enzyme, ATP-binding, Glycolysis, Kinase, Nucleotide-binding, Transferase
Deposited on 2009-05-28, released 2009-08-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hexokinase-3
    Species: Homo sapiens [TaxId:9606]
    Gene: HK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52790 (2-End)
      • expression tag (1)
    Domains in SCOPe 2.08: d3hm8a1, d3hm8a2, d3hm8a3
  • Chain 'B':
    Compound: Hexokinase-3
    Species: Homo sapiens [TaxId:9606]
    Gene: HK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52790 (2-End)
      • expression tag (1)
    Domains in SCOPe 2.08: d3hm8b1, d3hm8b2, d3hm8b3
  • Chain 'C':
    Compound: Hexokinase-3
    Species: Homo sapiens [TaxId:9606]
    Gene: HK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3hm8c1, d3hm8c2
  • Chain 'D':
    Compound: Hexokinase-3
    Species: Homo sapiens [TaxId:9606]
    Gene: HK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52790 (2-End)
      • expression tag (1)
    Domains in SCOPe 2.08: d3hm8d1, d3hm8d2, d3hm8d3
  • Heterogens: GLC, BG6

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3hm8A (A:)
gsrrlleetlapfrlnhdqlaavqaqmrkamakglrgeasslrmlptfvratpdgsergd
flaldlggtnfrvllvrvttgvqitseiysipetvaqgsgqqlfdhivdcivdfqqkqgl
sgqslplgftfsfpcrqlgldqgillnwtkgfkasdcegqdvvsllreaitrrqavelnv
vaivndtvgtmmscgyedprceiglivgtgtnacymeelrnvagvpgdsgrmcinmewga
fgddgslamlstrfdasvdqasinpgkqrfekmisgmylgeivrhillhltslgvlfrgq
qiqrlqtrdifktkflseiesdslalrqvrailedlglpltsddalmvlevcqavsqraa
qlcgagvaavvekirenrgleelavsvgvdgtlyklhprfsslvaatvrelaprcvvtfl
qsedgsgkgaalvtavacrlaqltr

    Sequence, based on observed residues (ATOM records): (download) 
    >3hm8A (A:)
srrlleetlapfrlnhdqlaavqaqmrkamakglrgeasslrmlptfvratpdgsergdf
laldlggtnfrvllvrvttgvqitseiysipetvaqgsgqqlfdhivdcivdfqqkqgls
gqslplgftfsfpcrqlgldqgillnwtkgfkasdcegqdvvsllreaitrrqavelnvv
aivndtvgtmmscgyedprceiglivgtgtnacymeelrnvagvpgdsgrmcinmewgaf
gddgslamlstrfdasvdqasinpgkqrfekmisgmylgeivrhillhltslgvlfrgqq
iqrlqtrdifktkflseiesdslalrqvrailedlglpltsddalmvlevcqavsqraaq
lcgagvaavvekirenrgleelavsvgvdgtlyklhprfsslvaatvrelaprcvvtflq
sedgsgkgaalvtavacrlaq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3hm8B (B:)
gsrrlleetlapfrlnhdqlaavqaqmrkamakglrgeasslrmlptfvratpdgsergd
flaldlggtnfrvllvrvttgvqitseiysipetvaqgsgqqlfdhivdcivdfqqkqgl
sgqslplgftfsfpcrqlgldqgillnwtkgfkasdcegqdvvsllreaitrrqavelnv
vaivndtvgtmmscgyedprceiglivgtgtnacymeelrnvagvpgdsgrmcinmewga
fgddgslamlstrfdasvdqasinpgkqrfekmisgmylgeivrhillhltslgvlfrgq
qiqrlqtrdifktkflseiesdslalrqvrailedlglpltsddalmvlevcqavsqraa
qlcgagvaavvekirenrgleelavsvgvdgtlyklhprfsslvaatvrelaprcvvtfl
qsedgsgkgaalvtavacrlaqltr

    Sequence, based on observed residues (ATOM records): (download) 
    >3hm8B (B:)
srrlleetlapfrlnhdqlaavqaqmrkamakglrgeasslrmlptfvratpdgsergdf
laldlggtnfrvllvrvttgvqitseiysipetvaqgsgqqlfdhivdcivdfqqkqgls
gqslplgftfsfpcrqlgldqgillnwtkgfkasdcegqdvvsllreaitrrqavelnvv
aivndtvgtmmscgyedprceiglivgtgtnacymeelrnvagvpgdsgrmcinmewgaf
gddgslamlstrfdasvdqasinpgkqrfekmisgmylgeivrhillhltslgvlfrgqq
iqrlqtrdifktkflseiesdslalrqvrailedlglpltsddalmvlevcqavsqraaq
lcgagvaavvekirenrgleelavsvgvdgtlyklhprfsslvaatvrelaprcvvtflq
sedgsgkgaalvtavacrlaq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3hm8C (C:)
gsrrlleetlapfrlnhdqlaavqaqmrkamakglrgeasslrmlptfvratpdgsergd
flaldlggtnfrvllvrvttgvqitseiysipetvaqgsgqqlfdhivdcivdfqqkqgl
sgqslplgftfsfpcrqlgldqgillnwtkgfkasdcegqdvvsllreaitrrqavelnv
vaivndtvgtmmscgyedprceiglivgtgtnacymeelrnvagvpgdsgrmcinmewga
fgddgslamlstrfdasvdqasinpgkqrfekmisgmylgeivrhillhltslgvlfrgq
qiqrlqtrdifktkflseiesdslalrqvrailedlglpltsddalmvlevcqavsqraa
qlcgagvaavvekirenrgleelavsvgvdgtlyklhprfsslvaatvrelaprcvvtfl
qsedgsgkgaalvtavacrlaqltr

    Sequence, based on observed residues (ATOM records): (download) 
    >3hm8C (C:)
rrlleetlapfrlnhdqlaavqaqmrkamakglrgeasslrmlptfvratpdgsergdfl
aldlggtnfrvllvrvttgvqitseiysipetvaqgsgqqlfdhivdcivdfqqkqglsg
qslplgftfsfpcrqlgldqgillnwtkgfkasdcegqdvvsllreaitrrqavelnvva
ivndtvgtmmscgyedprceiglivgtgtnacymeelrnvagvpgdsgrmcinmewgafg
ddgslamlstrfdasvdqasinpgkqrfekmisgmylgeivrhillhltslgvlfiqrlq
trdifktkflseiesdslalrqvrailedlglpltsddalmvlevcqavsqraaqlcgag
vaavvekirenrgleelavsvgvdgtlyklhprfsslvaatvrelaprcvvtflqsedgs
gkgaalvtavacrlaq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3hm8D (D:)
gsrrlleetlapfrlnhdqlaavqaqmrkamakglrgeasslrmlptfvratpdgsergd
flaldlggtnfrvllvrvttgvqitseiysipetvaqgsgqqlfdhivdcivdfqqkqgl
sgqslplgftfsfpcrqlgldqgillnwtkgfkasdcegqdvvsllreaitrrqavelnv
vaivndtvgtmmscgyedprceiglivgtgtnacymeelrnvagvpgdsgrmcinmewga
fgddgslamlstrfdasvdqasinpgkqrfekmisgmylgeivrhillhltslgvlfrgq
qiqrlqtrdifktkflseiesdslalrqvrailedlglpltsddalmvlevcqavsqraa
qlcgagvaavvekirenrgleelavsvgvdgtlyklhprfsslvaatvrelaprcvvtfl
qsedgsgkgaalvtavacrlaqltr

    Sequence, based on observed residues (ATOM records): (download) 
    >3hm8D (D:)
srrlleetlapfrlnhdqlaavqaqmrkamakglrgeasslrmlptfvratpdgsergdf
laldlggtnfrvllvrvttgvqitseiysipetvaqgsgqqlfdhivdcivdfqqkqgls
gqslplgftfsfpcrqlgldqgillnwtkgfkasdcegqdvvsllreaitrrqavelnvv
aivndtvgtmmscgyedprceiglivgtgtnacymeelrnvagvpgdsgrmcinmewgaf
gddgslamlstrfdasvdqasinpgkqrfekmisgmylgeivrhillhltslgvlfiqrl
qtrdifktkflseiesdslalrqvrailedlglpltsddalmvlevcqavsqraaqlcga
gvaavvekirenrgleelavsvgvdgtlyklhprfsslvaatvrelaprcvvtflqsedg
sgkgaalvtavacrlaq