PDB entry 3hky

View 3hky on RCSB PDB site
Description: HCV NS5B polymerase genotype 1b in complex with 1,5 benzodiazepine 6
Class: transferase
Keywords: HEPATITIS C VIRUS, 1, 5-BENZODIAZEPINE, genotype, NS5B, polymerase, Biacore, replicon, TRANSFERASE
Deposited on 2009-05-26, released 2010-05-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus subtype 1b [TaxId:31647]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot O92972 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.08: d3hkya1, d3hkya2
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus subtype 1b [TaxId:31647]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3hkyb_
  • Heterogens: IX6, SO4, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3hkyA (A:)
massmsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrl
qvlddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravn
hirsvwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalyd
vvstlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirvee
siyqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcyl
kataacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpe
ydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyap
tlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsy
spgeinrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklklt
pipaasqldlsgwfvagysggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3hkyA (A:)
ssmsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhi
rsvwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvv
stlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesi
yqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylka
taacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeyd
lelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptl
warmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsysp
geinrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpi
paasqldlsgwfvagysggdiyhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3hkyB (B:)
massmsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrl
qvlddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravn
hirsvwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalyd
vvstlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirvee
siyqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcyl
kataacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpe
ydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyap
tlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsy
spgeinrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklklt
pipaasqldlsgwfvagysggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3hkyB (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpgrkparlivfpdlgvrvcekmalydvvstlp
qavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqcc
dlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataac
raaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgein
rvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaas
qldlsgwfvagysggdiyhs