PDB entry 3h9f

View 3h9f on RCSB PDB site
Description: Crystal Structure of Human Dual Specificity Protein Kinase (TTK) in complex with a pyrimido-diazepin ligand
Class: transferase
Keywords: TTK, hMPS1, PYT, ESK, kinase, Dual Specificity, phosphotyrosine picked threonine kinase, SGC, Structural Genomics Consortium, ATP-binding, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Deposited on 2009-04-30, released 2009-05-19
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.21
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity protein kinase TTK
    Species: Homo sapiens [TaxId:9606]
    Gene: MPS1L1, TTK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P33981 (23-End)
      • expression tag (19-22)
    Domains in SCOPe 2.06: d3h9fa1, d3h9fa2
  • Heterogens: MG, 92M, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3h9fA (A:)
mhhhhhhssgvdlgtenlyfqsmsvkgriysilkqigsggsskvfqvlnekkqiyaikyv
nleeadnqtldsyrneiaylnklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkk
kksidpwerksywknmleavhtihqhgivhsdlkpanflivdgmlklidfgianqmqpdt
tsvvkdsqvgtvnymppeaikdmsssrengkskskispksdvwslgcilyymtygktpfq
qiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdpkqrisipellahpyvqiqt
hpvnqmakgttee

    Sequence, based on observed residues (ATOM records): (download) 
    >3h9fA (A:)
fqsmsvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiay
lnklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmlea
vhtihqhgivhsdlkpanflivdgmlklidfgianqmqpdttsgtvnymppeaikdmski
spksdvwslgcilyymtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkcc
lkrdpkqrisipellahpyvqiq