SCOPe 2.01: Structural Classification of Proteins

PDB entry 3h6f

View 3h6f on RCSB PDB site
Description: Crystal Structure of Mycobacterium Tuberculosis Proteasome Modified by inhibitor HT1171
Class: hydrolase
Keywords: Binding Sites, Oxazolidin-2-one, Crystallography, X-Ray, Mycobacterium tuberculosis, Protease Inhibitors, Proteasome Endopeptidase Complex, Protein Subunits, Substrate Specificity, Hydrolase, Proteasome
Deposited on 2009-04-23, released 2009-09-15
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-10-06, with a file datestamp of 2009-10-02.
Experiment type: XRAY
Resolution: 2.51 Å
R-factor: 0.216
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

Chain '1':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6f1_
Chain '2':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6f2_
Chain 'A':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6fa_
Chain 'B':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6fb_
Chain 'C':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6fc_
Chain 'D':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6fd_
Chain 'E':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6fe_
Chain 'F':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6ff_
Chain 'G':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6fg_
Chain 'H':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6fh_
Chain 'I':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6fi_
Chain 'J':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6fj_
Chain 'K':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6fk_
Chain 'L':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6fl_
Chain 'M':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6fm_
Chain 'N':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6fn_
Chain 'O':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6fo_
Chain 'P':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6fp_
Chain 'Q':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6fq_
Chain 'R':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6fr_
Chain 'S':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6fs_
Chain 'T':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6ft_
Chain 'U':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6fu_
Chain 'V':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6fv_
Chain 'W':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6fw_
Chain 'X':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6fx_
Chain 'Y':
Compound: Proteasome (Alpha subunit) PrcA
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: prcA, Rv2109c
Database cross-references and differences (RAF-indexed):
- Uniprot O33244
Domains in SCOPe 2.01: d3h6fy_
Chain 'Z':
Compound: Proteasome (Beta subunit) PrcB
Species: Mycobacterium tuberculosis [TaxId:1773]
Gene: MT2170, prcB, Rv2110c
Database cross-references and differences (RAF-indexed):
- Uniprot O33245 (1-End)
  - insertion (0)
Domains in SCOPe 2.01: d3h6fz_
Heterogens: DMF, HOH

PDB Chain Sequences:

Chain '1':
Sequence, based on SEQRES records: (download)

>3h6f1 (1:)
msfpyfispeqamrerselarkgiaraksvvalayaggvlfvaenpsrslqkiselydrv
gfaaagkfnefdnlrrggiqfadtrgyaydrrdvtgrqlanvyaqtlgtifteqakpyev
elcvaevahygetkrpelyritydgsiadephfvvmggttepianalkesyaenasltda
lriavaalragsadtsggdqptlgvaslevavldanrprrafrritgsalqallvdqesp
qsdgessg