PDB entry 3gnv

View 3gnv on RCSB PDB site
Description: HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 1b
Class: transferase
Keywords: HEPATITIS C VIRUS, 1.5-BENZODIAZEPINE, NS5B, SULFONE, polymerase, Apoptosis, ATP-binding, Capsid protein, Cell membrane, Endoplasmic reticulum, Envelope protein, Fusion protein, Glycoprotein, Helicase, Host-virus interaction, Hydrolase, Interferon antiviral system evasion, Lipid droplet, Lipoprotein, Membrane, Metal-binding, Mitochondrion, Multifunctional enzyme, Nucleotide-binding, Nucleotidyltransferase, Nucleus, Oncogene, Palmitate, Phosphoprotein, Protease, Ribonucleoprotein, RNA replication, RNA-binding, RNA-directed RNA polymerase, Secreted, Serine protease, SH3-binding, Thiol protease, Transcription, Transcription regulation, Transferase, Transmembrane, Viral nucleoprotein, Virion
Deposited on 2009-03-18, released 2009-10-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.177
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus isolate [TaxId:420174]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3gnva_
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus isolate [TaxId:420174]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3gnvb_
  • Heterogens: XNZ, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3gnvA (A:)
massmsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrl
qvlddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravn
hirsvwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalyd
vvstlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirvee
siyqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcyl
kataacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpe
ydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyap
tlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsy
spgeinrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklklt
pipaasqldlsgwfvagysggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3gnvA (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3gnvB (B:)
massmsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrl
qvlddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravn
hirsvwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalyd
vvstlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirvee
siyqccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcyl
kataacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpe
ydlelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyap
tlwarmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsy
spgeinrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklklt
pipaasqldlsgwfvagysggdiyhslsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3gnvB (B:)
smsytwtgalitpcaaeesklpllrhhnmvyattsrsaslrqkkvtfdrlqvlddhyrdv
lkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhirsvwedll
edtetpidttimaksevfcvqpgrkparlivfpdlgvrvcekmalydvvstlpqavmgss
ygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqccdlapear
qairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataacraaklqd
ctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydlelitscssnv
svahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarmilmthff
sillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgeinrvasclr
klgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaasqldlsgw
fvagysggdiyhs