PDB entry 3gft

View 3gft on RCSB PDB site
Description: Human K-Ras in complex with a GTP analogue
Class: signaling protein
Keywords: cancer, small gtpase, mutations, gtp analogue, Structural Genomics Consortium, SGC, Cardiomyopathy, Cell membrane, Deafness, Disease mutation, GTP-binding, Lipoprotein, Membrane, Methylation, Nucleotide-binding, Palmitate, Prenylation, Proto-oncogene, SIGNALING PROTEIN
Deposited on 2009-02-27, released 2009-03-10
The last revision prior to the SCOPe 2.02 freeze date was dated 2012-09-05, with a file datestamp of 2012-08-31.
Experiment type: XRAY
Resolution: 2.27 Å
R-factor: 0.215
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (18-End)
      • see remark 999 (78)
    Domains in SCOPe 2.02: d3gfta_
  • Chain 'B':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (18-End)
      • expression tag (15-17)
    Domains in SCOPe 2.02: d3gftb_
  • Chain 'C':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (18-End)
      • expression tag (14-17)
    Domains in SCOPe 2.02: d3gftc_
  • Chain 'D':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3gftd_
  • Chain 'E':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (18-End)
      • expression tag (15-17)
    Domains in SCOPe 2.02: d3gfte_
  • Chain 'F':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (18-End)
      • expression tag (15-17)
    Domains in SCOPe 2.02: d3gftf_
  • Heterogens: MG, GNP, UNX, CIT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3gftA (A:)
mhhhhhhssgrenlyfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrk
qvvidgetclldildtagheeysamrdqymrtgegflcvfainntksfedihhyreqikr
vkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvre
irkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >3gftA (A:)
mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
heeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdl
psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3gftB (B:)
mhhhhhhssgrenlyfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrk
qvvidgetclldildtagheeysamrdqymrtgegflcvfainntksfedihhyreqikr
vkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvre
irkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >3gftB (B:)
fqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldild
tagsamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlp
srtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3gftC (C:)
mhhhhhhssgrenlyfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrk
qvvidgetclldildtagheeysamrdqymrtgegflcvfainntksfedihhyreqikr
vkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvre
irkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >3gftC (C:)
yfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptdsyrkqvvidgetclldildt
agsamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlps
rtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3gftD (D:)
mhhhhhhssgrenlyfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrk
qvvidgetclldildtagheeysamrdqymrtgegflcvfainntksfedihhyreqikr
vkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvre
irkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >3gftD (D:)
mteyklvvvgaggvgksaltiqliqnhfvdedsyrkqvvidgetclldildtagmrtgeg
flcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsy
gipfietsaktrqgvddafytlvreirkhk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3gftE (E:)
mhhhhhhssgrenlyfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrk
qvvidgetclldildtagheeysamrdqymrtgegflcvfainntksfedihhyreqikr
vkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvre
irkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >3gftE (E:)
fqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldild
tagrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrt
vdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3gftF (F:)
mhhhhhhssgrenlyfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrk
qvvidgetclldildtagheeysamrdqymrtgegflcvfainntksfedihhyreqikr
vkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvre
irkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >3gftF (F:)
fqgmteyklvvvgaggvgksaltiqliqnhfvdedsyrkqvvidgetclldildtadqym
rtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrtvdtkqaqd
larsygipfietsaktrqgvddafytlvreirkhk