PDB entry 3g43

View 3g43 on RCSB PDB site
Description: Crystal structure of the calmodulin-bound Cav1.2 C-terminal regulatory domain dimer
Class: metal binding protein
Keywords: calmodulin-bound, coiled coil, calcium channel, Acetylation, Calcium, Methylation, Phosphoprotein, Polymorphism, Ubl conjugation, Alternative splicing, Brugada syndrome, Calcium transport, Disease mutation, Glycoprotein, Ion transport, Ionic channel, Membrane, Transmembrane, Transport, Voltage-gated channel, METAL BINDING PROTEIN
Deposited on 2009-02-03, released 2009-03-03
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-04-07, with a file datestamp of 2009-04-03.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.22
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Gene: CALM, CALM1, CALM2, CALM3, CALML2, CAM, CAM1, CAM2, CAM3, CAMB, CAMC, CAMIII
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3g43a_
  • Chain 'B':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Gene: CALM, CALM1, CALM2, CALM3, CALML2, CAM, CAM1, CAM2, CAM3, CAMB, CAMC, CAMIII
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3g43b_
  • Chain 'C':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Gene: CALM, CALM1, CALM2, CALM3, CALML2, CAM, CAM1, CAM2, CAM3, CAMB, CAMC, CAMIII
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3g43c_
  • Chain 'D':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Gene: CALM, CALM1, CALM2, CALM3, CALML2, CAM, CAM1, CAM2, CAM3, CAMB, CAMC, CAMIII
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3g43d_
  • Chain 'E':
    Compound: Voltage-dependent L-type calcium channel subunit alpha-1C
    Species: Homo sapiens [TaxId:9606]
    Gene: CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13936 (5-78)
      • expression tag (3-4)
  • Chain 'F':
    Compound: Voltage-dependent L-type calcium channel subunit alpha-1C
    Species: Homo sapiens [TaxId:9606]
    Gene: CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13936 (5-End)
      • expression tag (3-4)
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3g43A (A:)
adqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgn
gtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdee
vdemireadidgdgqvnyeefvqmmtak

    Sequence, based on observed residues (ATOM records): (download) 
    >3g43A (A:)
qlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgngt
idfpefltmmarkmk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3g43B (B:)
adqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgn
gtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdee
vdemireadidgdgqvnyeefvqmmtak

    Sequence, based on observed residues (ATOM records): (download) 
    >3g43B (B:)
dqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgng
tidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeev
demireadidgdgqvnyeefvqmmtak

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3g43C (C:)
adqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgn
gtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdee
vdemireadidgdgqvnyeefvqmmtak

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3g43D (D:)
adqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgn
gtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdee
vdemireadidgdgqvnyeefvqmmtak

    Sequence, based on observed residues (ATOM records): (download) 
    >3g43D (D:)
qlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgngt
idfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeevd
emireadidgdgqvnyeefvqmmtak

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.