PDB entry 3g0c

View 3g0c on RCSB PDB site
Description: Crystal structure of dipeptidyl peptidase IV in complex with a pyrimidinedione inhibitor 1
Class: hydrolase/hydrolase inhibitor
Keywords: DPP4, pyrimidinone, pyrimidindione, Aminopeptidase, Cell membrane, Glycoprotein, Hydrolase, Membrane, Protease, Secreted, Serine protease, Signal-anchor, Transmembrane, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2009-01-27, released 2010-02-16
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-02-02, with a file datestamp of 2011-01-28.
Experiment type: XRAY
Resolution: 2.69 Å
R-factor: 0.198
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: ADCP2, CD26, DPP4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3g0ca1, d3g0ca2
  • Chain 'B':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: ADCP2, CD26, DPP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27487 (12-739)
      • expression tag (9-11)
    Domains in SCOPe 2.03: d3g0cb1, d3g0cb2
  • Chain 'C':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: ADCP2, CD26, DPP4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3g0cc1, d3g0cc2
  • Chain 'D':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: ADCP2, CD26, DPP4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3g0cd1, d3g0cd2
  • Heterogens: RUF, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3g0cA (A:)
adpggshhhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygns
svflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqlitee
ripnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeee
vfsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptv
kffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmd
icdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicy
fqidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtcls
celnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqn
vqmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwaty
lasteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriai
wgwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrns
tvmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasst
ahqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >3g0cA (A:)
ktytltdylkntyrlklyslrwisdheylyknilvfnaeygnssvflenstfdefghsin
dysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwspvghk
layvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspngtfl
ayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssvtnat
siqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnclvar
qhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitkgtwe
vigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysvsfsk
eakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiilnetk
fwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfdgrgs
gyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmvlgsg
sgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqveylli
hgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfikqcf
slp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3g0cB (B:)
adpggshhhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygns
svflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqlitee
ripnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeee
vfsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptv
kffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmd
icdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicy
fqidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtcls
celnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqn
vqmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwaty
lasteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriai
wgwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrns
tvmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasst
ahqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >3g0cB (B:)
hhhsrktytltdylkntyrlklyslrwisdheylykqnilvfnaeygnssvflenstfde
fghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtw
spvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwws
pngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsls
svtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrw
nclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfi
tkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyy
svsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfi
ilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivas
fdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvts
mvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkq
veyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmsh
fikqcfslp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3g0cC (C:)
adpggshhhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygns
svflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqlitee
ripnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeee
vfsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptv
kffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmd
icdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicy
fqidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtcls
celnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqn
vqmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwaty
lasteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriai
wgwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrns
tvmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasst
ahqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >3g0cC (C:)
ktytltdylkntyrlklyslrwisdheylykqnilvfnaeygnssvflenstfdefghsi
ndysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwspvgh
klayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspngtf
layaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssvtna
tsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnclva
rqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitkgtw
evigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysvsfs
keakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiilnet
kfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfdgrg
sgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmvlgs
gsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqveyll
ihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfikqc
fslp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3g0cD (D:)
adpggshhhhhhsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygns
svflenstfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqlitee
ripnntqwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeee
vfsaysalwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptv
kffvvntdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmd
icdydessgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicy
fqidkkdctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtcls
celnpercqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqn
vqmpskkldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwaty
lasteniivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriai
wgwsyggyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrns
tvmsraenfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasst
ahqhiythmshfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >3g0cD (D:)
ktytltdylkntyrlklyslrwisdheylykqnilvfnaeygnssvflenstfdefghsi
ndysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwspvgh
klayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspngtf
layaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssvtna
tsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnclva
rqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitkgtw
evigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysvsfs
keakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiilnet
kfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfdgrg
sgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmvlgs
gsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqveyll
ihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfikqc
fslp