PDB entry 3g04

View 3g04 on RCSB PDB site
Description: Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody
Class: immune system
Keywords: tsh receptor, gpcr, thyroid, graves' disease, autoimmunity, receptor-autoantibody complex, immune system
Deposited on 2009-01-27, released 2009-08-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.184
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: human thyroid stimulating autoantibody m22 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3G04 (0-End)
    Domains in SCOPe 2.07: d3g04a1, d3g04a2
  • Chain 'B':
    Compound: human thyroid stimulating autoantibody m22 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3G04 (0-End)
  • Chain 'C':
    Compound: thyrotropin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: TSHR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3g04c_
  • Heterogens: NAG, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3g04A (A:)
    ltvltqppsvsgaprqrvtiscsgnssnignnavnwyqqlpgkapklliyyddqlpsgvs
    drfsgsrsgtsaslairglqsedeadyyctswddsldsqlfgggtrltvlgqpkaapsvt
    lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
    ylsltpeqwkshksyscqvthegstvektvaptecs
    

    Sequence, based on observed residues (ATOM records): (download)
    >3g04A (A:)
    ltvltqppsvsgaprqrvtiscsgnssnignnavnwyqqlpgkapklliyyddqlpsgvs
    drfsgsrsgtsaslairglqsedeadyyctswddsldsqlfgggtrltvlgqpkaapsvt
    lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
    ylsltpeqwkshksyscqvthegstvektvap
    

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3g04C (C:)
    mgcssppcechqeedfrvtckdiqripslppstqtlkliethlrtipshafsnlpnisri
    yvsidvtlqqleshsfynlskvthieirntrnltyidpdalkelpllkflgifntglkmf
    pdltkvystdiffileitdnpymtsipvnafqglcnetltlklynngftsvqgyafngtk
    ldavylnknkyltvidkdafggvysgpslldvsqtsvtalpskglehlkeliarntwtl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3g04C (C:)
    echqeedfrvtckdiqripslppstqtlkliethlrtipshafsnlpnisriyvsidvtl
    qqleshsfynlskvthieirntrnltyidpdalkelpllkflgifntglkmfpdltkvys
    tdiffileitdnpymtsipvnafqglcnetltlklynngftsvqgyafngtkldavylnk
    nkyltvidkdafggvysgpslldvsqtsvtalpskglehlkeliarnt