PDB entry 3fzl

View 3fzl on RCSB PDB site
Description: Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors
Class: chaperone
Keywords: HSP70, HSC70, BAG1, heat shock, chaperone, protein folding, adenosine, nucleotide, nucleotide exchange factor, small molecule inhibitor, ATP-binding, nucleotide-binding, stress response, apoptosis
Deposited on 2009-01-26, released 2009-03-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-03-31, with a file datestamp of 2009-03-27.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.217
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heat shock cognate 71 kDa protein
    Species: Homo sapiens [TaxId:9606]
    Gene: HSPA8, HSC70, HSP73, HSPA10
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3fzla1, d3fzla2
  • Chain 'B':
    Compound: BAG family molecular chaperone regulator 1
    Species: Homo sapiens [TaxId:9606]
    Gene: BAG1, HAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99933 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d3fzlb1, d3fzlb2
  • Heterogens: TRS, 3FD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3fzlA (A:)
    yfqgpavgidlgttyscvgvfqhgkveiiandqgnrttpsyvaftdterligdaaknqva
    mnptntvfdakrligrrfddavvqsdmkhwpfmvvndagrpkvqveykgetksfypeevs
    smvltkmkeiaeaylgktvtnavvtvpayfndsqrqatkdagtiaglnvlriineptaaa
    iaygldkkvgaernvlifdlgggtfdvsiltiedgifevkstagdthlggedfdnrmvnh
    fiaefkrkhkkdisenkravrrlrtacerakrtlssstqasieidslyegidfytsitra
    rfeelnadlfrgtldpvekalrdakldksqihdivlvggstripkiqkllqdffngkeln
    ksinpdeavaygaavqaails
    

    Sequence, based on observed residues (ATOM records): (download)
    >3fzlA (A:)
    pavgidlgttyscvgvfqhgkveiiandqgnrttpsyvaftdterligdaaknqvamnpt
    ntvfdakrligrrfddavvqsdmkhwpfmvvndagrpkvqveykgetksfypeevssmvl
    tkmkeiaeaylgktvtnavvtvpayfndsqrqatkdagtiaglnvlriineptaaaiayg
    ldkkvgaernvlifdlgggtfdvsiltiedgifevkstagdthlggedfdnrmvnhfiae
    fkrkhkkdisenkravrrlrtacerakrtlssstqasieidslyegidfytsitrarfee
    lnadlfrgtldpvekalrdakldksqihdivlvggstripkiqkllqdffngkelnksin
    pdeavaygaavqaails
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3fzlB (B:)
    gnspqeevelkklkhleksvekiadqleelnkeltgiqqgflpkdlqaealckldrrvka
    tieqfmkileeidtlilpenfkdsrlkrkglvkkvqaflaecdtveqnicqete
    

    Sequence, based on observed residues (ATOM records): (download)
    >3fzlB (B:)
    gnspqeevelkklkhleksvekiadqleelnkeltgiqqgflpkdlqaealckldrrvka
    tieqfmkileeidtlilpenfkdsrlkrkglvkkvqaflaecdtveqnicq