PDB entry 3fzd

View 3fzd on RCSB PDB site
Description: Mutation of Asn28 disrupts the enzymatic activity and dimerization of SARS 3CLpro
Class: hydrolase
Keywords: SARS, SARS 3CLpro, protease, SARS-CoV Mpro, Dimerization, Analytical Ultracentrifugation, Cytoplasm, Hydrolase, Membrane, Metal-binding, Ribosomal frameshifting, RNA-binding, Thiol protease, Transmembrane, Zinc, Zinc-finger
Deposited on 2009-01-25, released 2010-05-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-12, with a file datestamp of 2020-02-07.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3C-like proteinase
    Species: SARS coronavirus [TaxId:227859]
    Gene: 1a, SARS 3CL protease
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0C6U8 (2-300)
      • engineered (27)
    Domains in SCOPe 2.08: d3fzda_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3fzdA (A:)
    sgfrkmafpsgkvegcmvqvtcgtttlaglwlddtvycprhvictaedmlnpnyedllir
    ksnhsflvqagnvqlrvighsmqncllrlkvdtsnpktpkykfvriqpgqtfsvlacyng
    spsgvyqcamrpnhtikgsflngscgsvgfnidydcvsfcymhhmelptgvhagtdlegk
    fygpfvdrqtaqaagtdttitlnvlawlyaavingdrwflnrftttlndfnlvamkynye
    pltqdhvdilgplsaqtgiavldmcaalkellqngmngrtilgstiledeftpfdvvrqc
    s
    

    Sequence, based on observed residues (ATOM records): (download)
    >3fzdA (A:)
    frkmafpsgkvegcmvqvtcgtttlaglwlddtvycprhvictaedmlnpnyedllirks
    nhsflvqagnvqlrvighsmqncllrlkvdtsnpktpkykfvriqpgqtfsvlacyngsp
    sgvyqcamrpnhtikgngscgsvgfnidydcvsfcymhhmelptgvhagtdlegkfygpf
    vdrqtaqaagtdttitlnvlawlyaavingdrwflnrftttlndfnlvamkynyepltqd
    hvdilgplsaqtgiavldmcaalkellqngmngrtilgstiledeftpfdvvrqcs