PDB entry 3fxv
View 3fxv on RCSB PDB site
Description: Identification of an N-oxide pyridine GW4064 analogue as a potent FXR agonist
Class: hormone receptor
Keywords: NUCLEAR RECEPTOR, CHOLESTEROL, BILE ACID, DNA-binding, Metal-binding, Nucleus, Receptor, Transcription, Transcription regulation, Zinc, Zinc-finger, Activator, Acyltransferase, Alternative splicing, Chromosomal rearrangement, Phosphoprotein, Polymorphism, Proto-oncogene, Transferase, Ubl conjugation, hormone receptor
Deposited on
2009-01-21, released
2009-04-14
The last revision prior to the SCOPe 2.03 freeze date was dated
2009-04-21, with a file datestamp of
2009-04-17.
Experiment type: XRAY
Resolution: 2.26 Å
R-factor: 0.191
AEROSPACI score: 0.39
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: NR1H4 protein
Species: Homo sapiens [TaxId:9606]
Gene: NR1H4, hCG_20893
Database cross-references and differences (RAF-indexed):
- Uniprot A1L4K5 (4-231)
- expression tag (3)
- engineered (37)
- engineered (110)
Domains in SCOPe 2.03: d3fxva_ - Chain 'B':
Compound: 12-meric peptide from Nuclear receptor coactivator 1
Species: Homo sapiens, synthetic
Database cross-references and differences (RAF-indexed):
- Heterogens: 643, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3fxvA (A:)
gshmeltpdqqtllhfimdsynkqrmpqeitnkilkeafsaeenfliltematnhvqvlv
eftkklpgfqtldhedqiallkgsaveamflrsaeifnkklpsghsdllearirnsgisd
eyitpmfsfyksigelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklc
kihqpenpqhfacllgrltelrtfnhhhaemlmswrvndhkftpllceiwdvq
Sequence, based on observed residues (ATOM records): (download)
>3fxvA (A:)
meltpdqqtllhfimdsynkqrmpqeitnkilkeafsaeenfliltematnhvqvlveft
kklpgfqtldhedqiallkgsaveamflrsaeifnkhsdllearirnsgisdeyitpmfs
fyksigelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklckihqpenp
qhfacllgrltelrtfnhhhaemlmswrvhkftpllceiwdv
- Chain 'B':
No sequence available.