PDB entry 3flq
View 3flq on RCSB PDB site
Description: P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)-2-((s)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8h-pyrido[2,3-d]pyrimidin
Class: signaling protein, transferase
Keywords: P38; MAP KINASE; SERINE/THREONINE KINASE, Alternative splicing, ATP-binding, Cytoplasm, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transferase, SIGNALING PROTEIN
Deposited on
2008-12-19, released
2009-12-22
The last revision prior to the SCOPe 2.06 freeze date was dated
2009-12-22, with a file datestamp of
2009-12-18.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.235
AEROSPACI score: 0.43
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Mitogen-activated protein kinase 14
Species: Homo sapiens [TaxId:9606]
Gene: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d3flqa_ - Heterogens: 891, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3flqA (A:)
mrgshhhhhhgsmsqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktgl
rvavkklsrpfqsiihakrtyrelrllkhmkhenviglldvftparsleefndvylvthl
mgadlnnivkcqkltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkild
fglarhtddemtgyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdh
idqlklilrlvgtpgaellkkissesarnyiqsltqmpkmnfanvfiganplavdllekm
lvldsdkritaaqalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisf
vpppldqeemes
Sequence, based on observed residues (ATOM records): (download)
>3flqA (A:)
erptfyrqelnktiwevperyqnlspvggsvcaafdtktglrvavkklsrpfqsiihakr
tyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhv
qfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyvatrw
yrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaell
kkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahay
faqyhdpddepvadpydqsfesrdllidewksltydevisfvppp