PDB entry 3fhi

View 3fhi on RCSB PDB site
Description: Crystal structure of a complex between the catalytic and regulatory (RI{alpha}) subunits of PKA
Class: transferase
Keywords: cAMP, cAMP dependent protein kinase, Protein-Protein complex, AMP-PNP, Protein kinase Regulation, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, cAMP-dependent protein kinase activity, protein binding, ATP binding, kinase activity, transferase activity, ATP-binding, Kinase, Lipoprotein, Myristate, Nucleotide-binding, Nucleus, Phosphoprotein, Serine/threonine-protein kinase, Transferase, cAMP-binding
Deposited on 2008-12-09, released 2009-04-14
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.199
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase catalytic subunit alpha
    Species: Mus musculus [TaxId:10090]
    Gene: Prkaca, Pkaca
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05132 (Start-349)
      • engineered (198)
    Domains in SCOPe 2.02: d3fhia_
  • Chain 'B':
    Compound: cAMP-dependent protein kinase type I-alpha regulatory subunit
    Species: Bos taurus [TaxId:9913]
    Gene: PRKAR1A
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ANP, MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3fhiA (A:)
gnaaaakkgseqesvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlv
khkesgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvm
eyvaggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyi
qvtdfgfakrvkgrtwtlagtpeylapeiilskgynkavdwwalgvliyemaagyppffa
dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfatt
dwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkeftef

    Sequence, based on observed residues (ATOM records): (download) 
    >3fhiA (A:)
esvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnhyamk
ildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggemfshl
rrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvk
grtwtlagtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivs
gkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkvea
pfipkfkgpgdtsnfddyeeeeirvsinekcgkeftef

  • Chain 'B':
    No sequence available.