PDB entry 3f5x
View 3f5x on RCSB PDB site
Description: CDK-2-Cyclin complex with indazole inhibitor 9 bound at its active site
Class: Transferase/Cell cycle
Keywords: KINASE, PKC, PROTEIN KINASE, INHIBITOR, ATP-binding, Cell cycle, Cell division, Mitosis, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Cyclin, Nucleus, Transferase-Cell cycle COMPLEX
Deposited on
2008-11-04, released
2009-02-03
The last revision prior to the SCOPe 2.03 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-25.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.266
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cell division protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: CDK2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d3f5xa_ - Chain 'B':
Compound: Cyclin-A2
Species: Homo sapiens [TaxId:9606]
Gene: CCNA2, CCN1, CCNA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d3f5xb1, d3f5xb2 - Chain 'C':
Compound: Cell division protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: CDK2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d3f5xc_ - Chain 'D':
Compound: Cyclin-A2
Species: Homo sapiens [TaxId:9606]
Gene: CCNA2, CCN1, CCNA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d3f5xd1, d3f5xd2 - Heterogens: GOL, EZV, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3f5xA (A:)
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
Sequence, based on observed residues (ATOM records): (download)
>3f5xA (A:)
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpkrisakaalahpffqdvtkpvphlrl
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>3f5xB (B:)
dyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhlav
nyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrmeh
lvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsvia
gaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekykns
kyhgvsllnppetlnl
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>3f5xC (C:)
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
- Chain 'D':
Sequence, based on SEQRES records: (download)
>3f5xD (D:)
dyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhlav
nyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrmeh
lvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsvia
gaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekykns
kyhgvsllnppetlnl
Sequence, based on observed residues (ATOM records): (download)
>3f5xD (D:)
yhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhlavn
yidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrmehl
vlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsviag
aafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyknsk
yhgvsllnppetlnl