PDB entry 3ezr

View 3ezr on RCSB PDB site
Description: CDK-2 with indazole inhibitor 17 bound at its active site
Class: transferase
Keywords: KINASE, PKC, PROTEIN KINASE, INHIBITOR, ATP-binding, Cell cycle, Cell division, Mitosis, Nucleotide-binding, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transferase
Deposited on 2008-10-23, released 2009-02-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3ezra_
  • Heterogens: EZR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3ezrA (A:)
    gsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkel
    nhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafc
    hshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgck
    yystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykp
    sfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ezrA (A:)
    menfqkvekigegtygvvykarnkltgevvalkkirvpstaireisllkelnhpnivkll
    dvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrd
    lkpqnllintegaikladftlwyrapeillgckyystavdiwslgcifaemvtrralfpg
    dseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvppldedgrsllsq
    mlhydpnkrisakaalahpffqdvtkpvphlrl