PDB entry 3eyn

View 3eyn on RCSB PDB site
Description: Crystal structure of human acyl-coa synthetase medium-chain family member 2a (l64p mutation) in a complex with coa
Class: ligase
Keywords: MIDDLE-CHAIN ACYL-COA SYNTHETASE, XENOBIOTIC/MEDIUM-CHAIN FATTY ACID-COA LIGASE, ATP-BINDING, FATTY ACID METABOLISM, LIPID METABOLISM, MAGNESIUM, METAL-BINDING, MITOCHONDRION, NUCLEOTIDE-BINDING POLYMORPHISM, TRANSIT PEPTIDE, LIGASE, STRUCTURAL GENOMICS, SGC, STRUCTURAL GENOMICS CONSORTIUM, Nucleotide-binding, Polymorphism
Deposited on 2008-10-21, released 2008-11-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-04-07, with a file datestamp of 2009-04-03.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.169
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Acyl-coenzyme A synthetase ACSM2A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACSM2, ACSM2A, MACS2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08AH3
      • engineered (56)
    Domains in SCOPe 2.08: d3eyna_
  • Chain 'B':
    Compound: Acyl-coenzyme A synthetase ACSM2A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACSM2, ACSM2A, MACS2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08AH3
      • engineered (56)
    Domains in SCOPe 2.08: d3eynb_
  • Heterogens: MG, COA, UNK, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3eynA (A:)
mghhhhhhssgvdlgtenlyfqsmslqwghqevpakfnfasdvldhwadmekagkrppsp
alwwvngkgkelmwnfrelsensqqaanvlsgacglqrgdrvavvlprvpewwlvilgci
raglifmpgtiqmkstdilyrlqmskakaivagdeviqevdtvasecpslrikllvseks
cdgwlnfkkllneastthhcvetgsqeasaiyftsgtsglpkmaehsysslglkakmdag
wtglqasdimwtisdtgwilnilcslmepwalgactfvhllpkfdplvilktlssypiks
mmgapivyrmllqqdlssykfphlqncvtvgesllpetlenwraqtgldiresygqtetg
ltcmvsktmkikpgymgtaascydvqiiddkgnvlppgtegdigirvkpirpigifsgyv
dnpdktaanirgdfwllgdrgikdedgyfqfmgraddiinssgyrigpsevenalmehpa
vvetavisspdpvrgevvkafvvlasqflshdpeqltkelqqhvksvtapykyprkiefv
lnlpktvtgkiqraklrdkewkmsgkaraq

    Sequence, based on observed residues (ATOM records): (download) 
    >3eynA (A:)
ghqevpakfnfasdvldhwadmekagkrppspalwwvngkgkelmwnfrelsensqqaan
vlsgacglqrgdrvavvlprvpewwlvilgciraglifmpgtiqmkstdilyrlqmskak
aivagdeviqevdtvasecpslrikllvsekscdgwlnfkkllneastthhcvetgsqea
saiyftsgglpkmaehsysslglkakmdagwtglqasdimwtisdtgwilnilcslmepw
algactfvhllpkfdplvilktlssypiksmmgapivyrmllqqdlssykfphlqncvtv
gesllpetlenwraqtgldiresygqtetgltcmvsktmkikpgymgtaascydvqiidd
kgnvlppgtegdigirvkpirpigifsgyvdnpdktaanirgdfwllgdrgikdedgyfq
fmgraddiinssgyrigpsevenalmehpavvetavisspdpvrgevvkafvvlasqfls
hdpeqltkelqqhvksvtapykyprkiefvlnlpktvtgkiqraklrdkewk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3eynB (B:)
mghhhhhhssgvdlgtenlyfqsmslqwghqevpakfnfasdvldhwadmekagkrppsp
alwwvngkgkelmwnfrelsensqqaanvlsgacglqrgdrvavvlprvpewwlvilgci
raglifmpgtiqmkstdilyrlqmskakaivagdeviqevdtvasecpslrikllvseks
cdgwlnfkkllneastthhcvetgsqeasaiyftsgtsglpkmaehsysslglkakmdag
wtglqasdimwtisdtgwilnilcslmepwalgactfvhllpkfdplvilktlssypiks
mmgapivyrmllqqdlssykfphlqncvtvgesllpetlenwraqtgldiresygqtetg
ltcmvsktmkikpgymgtaascydvqiiddkgnvlppgtegdigirvkpirpigifsgyv
dnpdktaanirgdfwllgdrgikdedgyfqfmgraddiinssgyrigpsevenalmehpa
vvetavisspdpvrgevvkafvvlasqflshdpeqltkelqqhvksvtapykyprkiefv
lnlpktvtgkiqraklrdkewkmsgkaraq

    Sequence, based on observed residues (ATOM records): (download) 
    >3eynB (B:)
wghqevpakfnfasdvldhwadmekagkrppspalwwvngkgkelmwnfrelsensqqaa
nvlsgacglqrgdrvavvlprvpewwlvilgciraglifmpgtiqmkstdilyrlqmska
kaivagdeviqevdtvasecpslrikllvsekscdgwlnfkkllneastthhcvetgsqe
asaiyftsglpkmaehsysslglkakmdagwtglqasdimwtisdtgwilnilcslmepw
algactfvhllpkfdplvilktlssypiksmmgapivyrmllqqdlssykfphlqncvtv
gesllpetlenwraqtgldiresygqtetgltcmvsktmkikpgymgtaascydvqiidd
kgnvlppgtegdigirvkpirpigifsgyvdnpdktaanirgdfwllgdrgikdedgyfq
fmgraddiinssgyrigpsevenalmehpavvetavisspdpvrgevvkafvvlasqfls
hdpeqltkelqqhvksvtapykyprkiefvlnlpktvtgkiqraklrdkewk