PDB entry 3exi
View 3exi on RCSB PDB site
Description: Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex with the subunit-binding domain (SBD) of E2p, but SBD cannot be modeled into the electron density
Class: oxidoreductase
Keywords: heterotetramer; thiamine diphosphate-dependent enzyme; Disease mutation; Glycolysis; Leigh syndrome; Mitochondrion; Oxidoreductase; Phosphoprotein; Alternative splicing; Polymorphism; Pyruvate; Thiamine pyrophosphate; Transit peptide, OXIDOREDUCTASE
Deposited on
2008-10-16, released
2008-11-25
The last revision prior to the SCOPe 2.03 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.189
AEROSPACI score: 0.39
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: PDHA1, PHE1A
Database cross-references and differences (RAF-indexed):
- Uniprot P08559 (21-381)
- expression tag (11-20)
- engineered (109)
Domains in SCOPe 2.03: d3exia_ - Chain 'B':
Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: PDHB, PHE1B
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d3exib1, d3exib2 - Heterogens: K, CL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3exiA (A:)
mgsshhhhhhssglvprgshmfandatfeikkcdlhrleegppvttvltredglkyyrmm
qtvrrmelkadqlykqkiirgfchlcdgqeaccvgleaginptdhlitafrahgftftrg
lsvreilaeltgrkggcakgkggsmhmyaknfyggngivgaqvplgagialackyngkde
vcltlygdgaanqgqifeaynmaalwklpcificennrygmgtsveraaastdyykrgdf
ipglrvdgmdilcvreatrfaaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiq
evrsksdpimllkdrmvnsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhi
yssdppfevrganqwikfksvs
Sequence, based on observed residues (ATOM records): (download)
>3exiA (A:)
sglvprgshmfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkad
qlykqkiirgfchlcdgqeaccvgleaginptdhlitafrahgftftrglsvreilaelt
grkggcakgkggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaa
nqgqifeaynmaalwklpcificennrtdyykrgdfipglrvdgmdilcvreatrfaaay
crsgkgpilmelqtysdpimllkdrmvnsnlasveelkeidvevrkeiedaaqfatadpe
ppleelgyhiyssdppfevrganqwikfksvs
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>3exiB (B:)
lqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpisem
gfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpnga
sagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvpf
efppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmrt
irpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgadv
pmpyakilednsipqvkdiifaikktlni