PDB entry 3exe

View 3exe on RCSB PDB site
Description: Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex
Class: oxidoreductase
Keywords: heterotetramer; thiamine diphosphate-dependent enzyme; Disease mutation; Glycolysis; Leigh syndrome; Mitochondrion; Oxidoreductase; Phosphoprotein; Alternative splicing; Polymorphism; Pyruvate; Thiamine pyrophosphate; Transit peptide, OXIDOREDUCTASE
Deposited on 2008-10-16, released 2008-11-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: 0.161
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (21-381)
      • expression tag (19-20)
    Domains in SCOPe 2.06: d3exea1, d3exea2
  • Chain 'B':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3exeb1, d3exeb2
  • Chain 'C':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (21-381)
      • expression tag (20)
    Domains in SCOPe 2.06: d3exec1, d3exec2
  • Chain 'D':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3exed1, d3exed2
  • Chain 'E':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3exee_
  • Chain 'F':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3exef1, d3exef2
  • Chain 'G':
    Compound: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHA1, PHE1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08559 (21-381)
      • expression tag (20)
    Domains in SCOPe 2.06: d3exeg1, d3exeg2
  • Chain 'H':
    Compound: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDHB, PHE1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3exeh1, d3exeh2
  • Heterogens: MN, TPP, K, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3exeA (A:)
    mgsshhhhhhssglvprgshmfandatfeikkcdlhrleegppvttvltredglkyyrmm
    qtvrrmelkadqlykqkiirgfchlcdgqeaccvgleaginptdhlitayrahgftftrg
    lsvreilaeltgrkggcakgkggsmhmyaknfyggngivgaqvplgagialackyngkde
    vcltlygdgaanqgqifeaynmaalwklpcificennrygmgtsveraaastdyykrgdf
    ipglrvdgmdilcvreatrfaaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiq
    evrsksdpimllkdrmvnsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhi
    yssdppfevrganqwikfksvs
    

    Sequence, based on observed residues (ATOM records): (download)
    >3exeA (A:)
    hmfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkii
    rgfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcak
    gkggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifea
    ynmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvreatr
    faaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiqevrsksdpimllkdrmvns
    nlasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfk
    svs
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3exeB (B:)
    lqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpisem
    gfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpnga
    sagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvpf
    efppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmrt
    irpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgadv
    pmpyakilednsipqvkdiifaikktlni
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3exeC (C:)
    mgsshhhhhhssglvprgshmfandatfeikkcdlhrleegppvttvltredglkyyrmm
    qtvrrmelkadqlykqkiirgfchlcdgqeaccvgleaginptdhlitayrahgftftrg
    lsvreilaeltgrkggcakgkggsmhmyaknfyggngivgaqvplgagialackyngkde
    vcltlygdgaanqgqifeaynmaalwklpcificennrygmgtsveraaastdyykrgdf
    ipglrvdgmdilcvreatrfaaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiq
    evrsksdpimllkdrmvnsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhi
    yssdppfevrganqwikfksvs
    

    Sequence, based on observed residues (ATOM records): (download)
    >3exeC (C:)
    mfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
    gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
    kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
    nmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvreatrf
    aaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiqevrsksdpimllkdrmvnsn
    lasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfks
    vs
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3exeD (D:)
    lqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpisem
    gfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpnga
    sagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvpf
    efppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmrt
    irpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgadv
    pmpyakilednsipqvkdiifaikktlni
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >3exeE (E:)
    mgsshhhhhhssglvprgshmfandatfeikkcdlhrleegppvttvltredglkyyrmm
    qtvrrmelkadqlykqkiirgfchlcdgqeaccvgleaginptdhlitayrahgftftrg
    lsvreilaeltgrkggcakgkggsmhmyaknfyggngivgaqvplgagialackyngkde
    vcltlygdgaanqgqifeaynmaalwklpcificennrygmgtsveraaastdyykrgdf
    ipglrvdgmdilcvreatrfaaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiq
    evrsksdpimllkdrmvnsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhi
    yssdppfevrganqwikfksvs
    

    Sequence, based on observed residues (ATOM records): (download)
    >3exeE (E:)
    fandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiirg
    fchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakgk
    ggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeayn
    maalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvreatrfa
    aaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiqevrsksdpimllkdrmvnsnl
    asveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfksv
    s
    

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3exeF (F:)
    lqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpisem
    gfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpnga
    sagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvpf
    efppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmrt
    irpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgadv
    pmpyakilednsipqvkdiifaikktlni
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >3exeG (G:)
    mgsshhhhhhssglvprgshmfandatfeikkcdlhrleegppvttvltredglkyyrmm
    qtvrrmelkadqlykqkiirgfchlcdgqeaccvgleaginptdhlitayrahgftftrg
    lsvreilaeltgrkggcakgkggsmhmyaknfyggngivgaqvplgagialackyngkde
    vcltlygdgaanqgqifeaynmaalwklpcificennrygmgtsveraaastdyykrgdf
    ipglrvdgmdilcvreatrfaaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiq
    evrsksdpimllkdrmvnsnlasveelkeidvevrkeiedaaqfatadpeppleelgyhi
    yssdppfevrganqwikfksvs
    

    Sequence, based on observed residues (ATOM records): (download)
    >3exeG (G:)
    mfandatfeikkcdlhrleegppvttvltredglkyyrmmqtvrrmelkadqlykqkiir
    gfchlcdgqeaccvgleaginptdhlitayrahgftftrglsvreilaeltgrkggcakg
    kggsmhmyaknfyggngivgaqvplgagialackyngkdevcltlygdgaanqgqifeay
    nmaalwklpcificennrygmgtsveraaastdyykrgdfipglrvdgmdilcvreatrf
    aaaycrsgkgpilmelqtyryhghsmsdpgvsyrtreeiqevrsksdpimllkdrmvnsn
    lasveelkeidvevrkeiedaaqfatadpeppleelgyhiyssdppfevrganqwikfks
    vs
    

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3exeH (H:)
    lqvtvrdainqgmdeelerdekvfllgeevaqydgaykvsrglwkkygdkriidtpisem
    gfagiavgaamaglrpicefmtfnfsmqaidqvinsaaktyymsgglqpvpivfrgpnga
    sagvaaqhsqcfaawyghcpglkvvspwnsedakgliksairdnnpvvvlenelmygvpf
    efppeaqskdflipigkakierqgthitvvshsrpvghcleaaavlskegvecevinmrt
    irpmdmetieasvmktnhlvtveggwpqfgvgaeicarimegpafnfldapavrvtgadv
    pmpyakilednsipqvkdiifaikktlni