PDB entry 3eqf

View 3eqf on RCSB PDB site
Description: X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with K252A and MG2P
Class: transferase
Keywords: MEK1 KINASE, ATP-binding, Disease mutation, Kinase, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Deposited on 2008-09-30, released 2009-02-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.318
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity mitogen-activated protein kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K1, MEK1, PRKMK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3eqfa_
  • Heterogens: KSA, MG, CA, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3eqfA (A:)
gkkleeleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglv
marklihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldq
vlkkagripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsg
qlidsmansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelel
mfgcqvegdaaetpprprtpgrplnkfgmdsrppmaifelldyivnepppklpsgvfsle
fqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnqpstpthaagv

    Sequence, based on observed residues (ATOM records): (download) 
    >3eqfA (A:)
eleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarkl
ihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkka
gripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlids
mansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcp
maifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdae
evdfagwlcstigl