PDB entry 3eo1

View 3eo1 on RCSB PDB site
Description: Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3
Class: immune system/cytokine
Keywords: Antibody-cytokine complex, Growth factor, FAB fragment, Cardiomyopathy, Cleavage on pair of basic residues, Glycoprotein, Mitogen, Polymorphism, Secreted, IMMUNE SYSTEM/CYTOKINE COMPLEX
Deposited on 2008-09-26, released 2008-12-02
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-01-06, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.255
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GC-1008 Fab Light Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3EO1 (0-214)
    Domains in SCOPe 2.05: d3eo1a1, d3eo1a2
  • Chain 'B':
    Compound: GC-1008 Fab Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3EO1 (0-End)
  • Chain 'C':
    Compound: Transforming growth factor beta-3
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3eo1c_
  • Chain 'D':
    Compound: GC-1008 Fab Light Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3EO1 (0-214)
    Domains in SCOPe 2.05: d3eo1d1, d3eo1d2
  • Chain 'E':
    Compound: GC-1008 Fab Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3EO1 (0-End)
  • Chain 'F':
    Compound: Transforming growth factor beta-3
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3eo1f_
  • Chain 'G':
    Compound: GC-1008 Fab Light Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3EO1 (0-214)
    Domains in SCOPe 2.05: d3eo1g1, d3eo1g2
  • Chain 'H':
    Compound: GC-1008 Fab Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3EO1 (0-End)
  • Chain 'I':
    Compound: Transforming growth factor beta-3
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3eo1i_
  • Chain 'J':
    Compound: GC-1008 Fab Light Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3EO1 (0-214)
    Domains in SCOPe 2.05: d3eo1j1, d3eo1j2
  • Chain 'K':
    Compound: GC-1008 Fab Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3EO1 (0-End)
  • Chain 'L':
    Compound: Transforming growth factor beta-3
    Species: Homo sapiens [TaxId:9606]
    Gene: TGFB3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3eo1l_

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3eo1A (A:)
etvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgip
drfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3eo1C (C:)
aldtnycfrnleenccvrplyidfrqdlgwkwvhepkgyyanfcsgpcpylrsadtthst
vlglyntlnpeasaspccvpqdlepltilyyvgrtpkveqlsnmvvksckcs

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3eo1D (D:)
etvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgip
drfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3eo1F (F:)
aldtnycfrnleenccvrplyidfrqdlgwkwvhepkgyyanfcsgpcpylrsadtthst
vlglyntlnpeasaspccvpqdlepltilyyvgrtpkveqlsnmvvksckcs

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3eo1G (G:)
etvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgip
drfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3eo1I (I:)
aldtnycfrnleenccvrplyidfrqdlgwkwvhepkgyyanfcsgpcpylrsadtthst
vlglyntlnpeasaspccvpqdlepltilyyvgrtpkveqlsnmvvksckcs

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3eo1J (J:)
etvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgip
drfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3eo1L (L:)
aldtnycfrnleenccvrplyidfrqdlgwkwvhepkgyyanfcsgpcpylrsadtthst
vlglyntlnpeasaspccvpqdlepltilyyvgrtpkveqlsnmvvksckcs