PDB entry 3enm

View 3enm on RCSB PDB site
Description: The structure of the MAP2K MEK6 reveals an autoinhibitory dimer
Class: transferase
Keywords: MEK6, autoinhibited dimer, ATP-binding, Kinase, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Deposited on 2008-09-25, released 2009-03-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.215
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity mitogen-activated protein kinase kinase 6
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52564 (Start-314)
      • engineered (189)
      • expression tag (315)
    Domains in SCOPe 2.08: d3enma1, d3enma2
  • Chain 'B':
    Compound: Dual specificity mitogen-activated protein kinase kinase 6
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52564 (Start-314)
      • engineered (189)
    Domains in SCOPe 2.08: d3enmb_
  • Chain 'C':
    Compound: Dual specificity mitogen-activated protein kinase kinase 6
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52564 (Start-314)
      • engineered (189)
      • expression tag (315)
    Domains in SCOPe 2.08: d3enmc1, d3enmc2
  • Chain 'D':
    Compound: Dual specificity mitogen-activated protein kinase kinase 6
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52564 (27-314)
      • expression tag (25-26)
      • engineered (189)
      • expression tag (315)
    Domains in SCOPe 2.08: d3enmd1, d3enmd2, d3enmd3
  • Heterogens: SO4, GOL, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3enmA (A:)
    msyyhhhhhhdydipttenlyfqgamenfevkaddlepimelgrgaygvvekmrhvpsgq
    imavkriratvnsqeqkrllmdldismrtvdcpftvtfygalfregdvwicmelmdtsld
    kfykqvidkgqtipedilgkiavsivkalehlhsklsvihrdvkpsnvlinalgqvkmcd
    fgisgylvddvakdidagckpymaperinpelnqkgysvksdiwslgitmielailrfpy
    dswgtpfqqlkqvveepspqlpadkfsaefvdftsqclkknskerptypelmqhpfftlh
    eskgtdvasfvklila
    

    Sequence, based on observed residues (ATOM records): (download)
    >3enmA (A:)
    fevkaddlepimelgrgaygvvekmrhvpsgqimavkriratvnsqeqkrllmdldismr
    tvdcpftvtfygalfregdvwicmelmdtsldkfykqvidkgqtipedilgkiavsivka
    lehlhsklsvihrdvkpsnvlinalgqvkmcdfgisgylvddkpymaperinpelnqkgy
    svksdiwslgitmielailrfpydswgtpfqqlkqvveepspqlpadkfsaefvdftsqc
    lkknskerptypelmqhpfftlheskgtdvasfvklila
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3enmB (B:)
    msyyhhhhhhdydipttenlyfqgamenfevkaddlepimelgrgaygvvekmrhvpsgq
    imavkriratvnsqeqkrllmdldismrtvdcpftvtfygalfregdvwicmelmdtsld
    kfykqvidkgqtipedilgkiavsivkalehlhsklsvihrdvkpsnvlinalgqvkmcd
    fgisgylvddvakdidagckpymaperinpelnqkgysvksdiwslgitmielailrfpy
    dswgtpfqqlkqvveepspqlpadkfsaefvdftsqclkknskerptypelmqhpfftlh
    eskgtdvasfvklila
    

    Sequence, based on observed residues (ATOM records): (download)
    >3enmB (B:)
    kaddlmelgrgaygvvekmrhvpsgqimavkriratvnsqeqkrllmdldismrtvdcpf
    tvtfygalfregdvwicmelmdtsldkfykqvidkgqtipedilgkiavsivkalehlhs
    klsvihrdvkpsnvlinalgqvkmcdfgisgylvddvkpymaperinpelnqksvksdiw
    slgitmielailrfpydswgtpfqqlkqvveepspqlpadkfsaefvdftsqclkknske
    rptypelmqhpfftlheskgtdvasfvklil
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3enmC (C:)
    msyyhhhhhhdydipttenlyfqgamenfevkaddlepimelgrgaygvvekmrhvpsgq
    imavkriratvnsqeqkrllmdldismrtvdcpftvtfygalfregdvwicmelmdtsld
    kfykqvidkgqtipedilgkiavsivkalehlhsklsvihrdvkpsnvlinalgqvkmcd
    fgisgylvddvakdidagckpymaperinpelnqkgysvksdiwslgitmielailrfpy
    dswgtpfqqlkqvveepspqlpadkfsaefvdftsqclkknskerptypelmqhpfftlh
    eskgtdvasfvklila
    

    Sequence, based on observed residues (ATOM records): (download)
    >3enmC (C:)
    vkaddlepimelgrgaygvvekmrhvpsgqimavkriratvnsqeqkrllmdldismrtv
    dcpftvtfygalfregdvwicmelmdtsldkfykqvidkgqtipedilgkiavsivkale
    hlhsklsvihrdvkpsnvlinalgqvkmcdfgisgylvddvkpymaperinpelnqsvks
    diwslgitmielailrfpydswgtpfqqlkqvveepspqlpadkfsaefvdftsqclkkn
    skerptypelmqhpfftlheskgtdvasfvklila
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >3enmD (D:)
    msyyhhhhhhdydipttenlyfqgamenfevkaddlepimelgrgaygvvekmrhvpsgq
    imavkriratvnsqeqkrllmdldismrtvdcpftvtfygalfregdvwicmelmdtsld
    kfykqvidkgqtipedilgkiavsivkalehlhsklsvihrdvkpsnvlinalgqvkmcd
    fgisgylvddvakdidagckpymaperinpelnqkgysvksdiwslgitmielailrfpy
    dswgtpfqqlkqvveepspqlpadkfsaefvdftsqclkknskerptypelmqhpfftlh
    eskgtdvasfvklila
    

    Sequence, based on observed residues (ATOM records): (download)
    >3enmD (D:)
    menfevkaddlepimelgrgaygvvekmrhvpsgqimavkriratvnsqeqkrllmdldi
    smrtvdcpftvtfygalfregdvwicmelmdtsldkfykqvidkgqtipedilgkiavsi
    vkalehlhsklsvihrdvkpsnvlinalgqvkmcdfgisgylvddkpymaperinpelnq
    kgysvksdiwslgitmielailrfpydswgtpfqqlkqvveepspqlpadkfsaefvdft
    sqclkknskerptypelmqhpfftlheskgtdvasfvklila