PDB entry 3en5
View 3en5 on RCSB PDB site
Description: Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP494, a multitargeted kinase inhibitor
Class: transferase
Keywords: SRC, tyrosine, kinase, polypharmacology, inhibitor, multitarget, phosphoinositide, transferase, signaling, pyrazolopyrimidine, kinase-inhibitor complex, ATP-binding, Lipoprotein, Myristate, Nucleotide-binding, Phosphoprotein, Proto-oncogene, SH2 domain, SH3 domain, Tyrosine-protein kinase
Deposited on
2008-09-25, released
2008-10-14
The last revision prior to the SCOPe 2.04 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 2.66 Å
R-factor: 0.206
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proto-oncogene tyrosine-protein kinase Src
Species: Gallus gallus [TaxId:9031]
Gene: SRC
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d3en5a_ - Chain 'B':
Compound: Proto-oncogene tyrosine-protein kinase Src
Species: Gallus gallus [TaxId:9031]
Gene: SRC
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d3en5b_ - Heterogens: KS4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3en5A (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl
Sequence, based on observed residues (ATOM records): (download)
>3en5A (A:)
weipreslrlevklgqgfgevwmgtwngttrvaiktlqvmkklrheklvqlyavvseepi
yivteymskgslldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlraanilv
genlvckvapikwtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqv
ergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3en5B (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl
Sequence, based on observed residues (ATOM records): (download)
>3en5B (B:)
akdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmk
klrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgma
yvermnyvhrdlraanilvgenlvckvadfglpikwtapeaalygrftiksdvwsfgill
telttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeyl
qafledyftstepqyqpgenl