PDB entry 3e9s

View 3e9s on RCSB PDB site
Description: A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
Class: Hydrolase
Keywords: SARS, virus, coronavirus, papain, papain-like, protease, PLpro, nsp3, Cytoplasm, Hydrolase, Membrane, Metal-binding, Ribosomal frameshifting, RNA-binding, Thiol protease, Transmembrane, Zinc, Zinc-finger
Deposited on 2008-08-23, released 2008-10-07
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.196
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: non-structural protein 3
    Species: SARS coronavirus [TaxId:227859]
    Gene: 1a
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0C6U8 (3-End)
      • expression tag (0-2)
    Domains in SCOPe 2.06: d3e9sa1, d3e9sa2, d3e9sa3
  • Heterogens: TTT, ZN, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3e9sA (A:)
    asmevktikvfttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktffv
    lpsddtlrseafeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssvl
    lalqqlevkfnapalqeayyraragdaanfcalilaysnktvgelgdvretmthllqhan
    lesakrvlnvvckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvqq
    essfvmmsappaeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmseyk
    gpvtdvfyketsytttik
    

    Sequence, based on observed residues (ATOM records): (download)
    >3e9sA (A:)
    asmevktikvfttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktffv
    lpsddtlrseafeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssvl
    lalqqlevkfnapalqeayyraragdaanfcalilaysnktvgelgdvretmthllqhan
    lesakrvlnvvckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvqq
    essfvmmsappaeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmseyk
    gpvtdvfyketsyttti