PDB entry 3e8a

View 3e8a on RCSB PDB site
Description: Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(l-Thiophosphate) and Low Ca Concentration
Class: lyase/lyase inhibitor
Keywords: ADENYLYL CYCLASE, G(S)ALPHA, ATP-ALPHAS, Alternative splicing, cAMP biosynthesis, Glycoprotein, Lyase, Magnesium, Membrane, Metal-binding, Phosphoprotein, Transmembrane, Cell membrane, GTP-binding, Lipoprotein, Nucleotide-binding, Palmitate, Transducer, LYASE-LYASE INHIBITOR COMPLEX
Deposited on 2008-08-19, released 2009-05-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-04-07, with a file datestamp of 2010-04-02.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.242
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Adenylate cyclase type 5
    Species: Canis lupus familiaris [TaxId:9615]
    Gene: ADCY5, Adenylyl cyclase Type V
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30803
      • engineered (120)
    Domains in SCOPe 2.08: d3e8aa_
  • Chain 'B':
    Compound: Adenylate cyclase type 2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Adcy2, Adenylyl cyclase Type II
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3e8ab_
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Bos taurus [TaxId:9913]
    Gene: GNAS, GNAS1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: FKP, CA, AGS, MG, GSP, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3e8aA (A:)
mhhhhhhamemkadinakqedmmfhkiyiqkhdnvsilfadiegftslasqctaqelvmt
lnelfarfdklaaenhclrikilgdcyycvsglpearadhahccvemgmdmieaislvre
mtgvnvnmrvgihsgrvhcgvlglrkwqfdvwsndvtlanhmeaggkagrihitkatlsy
lngdyevepgcggernaylkehsietflilrctqkrkeekamiak

    Sequence, based on observed residues (ATOM records): (download) 
    >3e8aA (A:)
dmmfhkiyiqkhdnvsilfadiegftslasqctaqelvmtlnelfarfdklaaenhclri
kilgdcyycvsglpearadhahccvemgmdmieaislvremtgvnvnmrvgihsgrvhcg
vlglrkwqfdvwsndvtlanhmeaggkagrihitkatlsylngdyevepgcggernaylk
ehsietflil

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3e8aB (B:)
rslkneelyhqsydcvcvmfasipdfkefytesdvnkegleclrllneiiadfddllskp
kfsgvekiktigstymaatglsaipsqehaqeperqymhigtmvefayalvgkldainkh
sfndfklrvginhgpviagvigaqkpqydiwgntvnvasrmdstgvldkiqvteetslil
qtlgytctcrgiinvkgkgdlktyfvntemsr

    Sequence, based on observed residues (ATOM records): (download) 
    >3e8aB (B:)
hqsydcvcvmfasipdfkefytesdvnkegleclrllneiiadfddllskpkfsgvekik
tigstymaatglsarqymhigtmvefayalvgkldainkhsfndfklrvginhgpviagv
igaqkpqydiwgntvnvasrmdstgvldkiqvteetslilqtlgytctcrgiinvkgkgd
lktyfvnt

  • Chain 'C':
    No sequence available.