PDB entry 3e88
View 3e88 on RCSB PDB site
Description: Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors
Class: transferase
Keywords: AKT2, kinase, GSK3 beta, ATP-binding, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Wnt signaling pathway
Deposited on
2008-08-19, released
2008-10-14
The last revision prior to the SCOPe 2.01 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.232
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: rac-beta serine/threonine-protein kinase
Species: Homo sapiens [TaxId:9606]
Gene: AKT2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d3e88a_ - Chain 'B':
Compound: rac-beta serine/threonine-protein kinase
Species: Homo sapiens [TaxId:9606]
Gene: AKT2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d3e88b_ - Chain 'C':
Compound: Glycogen synthase kinase-3 beta peptide
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: Glycogen synthase kinase-3 beta peptide
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Heterogens: G96, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3e88A (A:)
kvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvtesrvlq
ntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaley
lhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylapevledn
dygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksllagll
kkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfddefta
qsititppdrydslglleldqrthfpqfdysasir
Sequence, based on observed residues (ATOM records): (download)
>3e88A (A:)
kvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvtesrvlq
ntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaley
lhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylapevledn
dygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksllagll
kkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfddefta
qsititqrthfpqfdysasir
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3e88B (B:)
kvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvtesrvlq
ntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaley
lhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylapevledn
dygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksllagll
kkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfddefta
qsititppdrydslglleldqrthfpqfdysasir
Sequence, based on observed residues (ATOM records): (download)
>3e88B (B:)
kvtmndfdylkllgkgtfgkvilvrekatgryyamkilrkeviiakdevahtvtesrvlq
ntrhpfltalkyafqthdrlcfvmeyanggelffhlsrervfteerarfygaeivsaley
lhsrdvvyrdiklenlmldkdghikitdfglckegisdgatmktfcgtpeylapevledn
dygravdwwglgvvmyemmcgrlpfynqdherlfelilmeeirfprtlspeaksllagll
kkdpkqrlgggpsdakevmehrfflsinwqdvvqkkllppfkpqvtsevdtryfddefta
qsititqrthfpqfdysasir
- Chain 'C':
No sequence available.
- Chain 'D':
No sequence available.