PDB entry 3e50
View 3e50 on RCSB PDB site
Description: Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha
Class: Hydrolase/Hormone
Keywords: IDE, TGF-ALPHA, Cytoplasm, Hydrolase, Metal-binding, Metalloprotease, Polymorphism, Protease, Zinc, Cell membrane, EGF-like domain, Glycoprotein, Growth factor, Lipoprotein, Membrane, Mitogen, Palmitate, Secreted, Transmembrane, Hydrolase/Hormone COMPLEX
Deposited on
2008-08-12, released
2009-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated
2010-02-09, with a file datestamp of
2010-02-05.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.193
AEROSPACI score: 0.36
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Insulin-degrading enzyme
Species: Homo sapiens [TaxId:9606]
Gene: hCG_1810909, IDE, RP11-366I13.1-001
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: Insulin-degrading enzyme
Species: Homo sapiens [TaxId:9606]
Gene: hCG_1810909, IDE, RP11-366I13.1-001
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: Protransforming growth factor alpha
Species: Homo sapiens [TaxId:9606]
Gene: TGFA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3e50c_ - Chain 'D':
Compound: Protransforming growth factor alpha
Species: Homo sapiens [TaxId:9606]
Gene: TGFA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3e50d_ - Heterogens: ZN, HOH