PDB entry 3drs

View 3drs on RCSB PDB site
Description: HIV reverse transcriptase K103N mutant in complex with inhibitor R8D
Class: transferase
Keywords: HIV-1 reverse transcriptase, non-nucleoside inhibition, nucleotidyltrasferase, Hydrolase, Transferase
Deposited on 2008-07-11, released 2008-10-14
The last revision prior to the SCOP 1.75 freeze date was dated 2008-10-28, with a file datestamp of 2008-10-24.
Experiment type: XRAY
Resolution: 3.15 Å
R-factor: 0.187
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus type 1 [TaxId:11706]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (3-End)
      • expression tag (2)
      • engineered (105)
    Domains in SCOP 1.75: d3drsa1
  • Chain 'B':
    Compound: p66 RT
    Species: Human immunodeficiency virus type 1 [TaxId:11706]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585
      • engineered (105)
    Domains in SCOP 1.75: d3drsb1
  • Heterogens: R8D

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3drsA (A:)
    mnspispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyn
    tpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkknksvtvldvgdayfs
    vpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpd
    iviyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpd
    kwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplte
    eaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarm
    rgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefv
    ntpplvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqkt
    elqaiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvp
    ahkgiggneqvdklvsagirkvl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3drsA (A:)
    spispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntp
    vfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkknksvtvldvgdayfsvp
    ldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiv
    iyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkw
    tvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteea
    elelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrg
    ahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvnt
    pplvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktel
    qaiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpah
    kgiggneqv
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3drsB (B:)
    mnspispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyn
    tpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkknksvtvldvgdayfs
    vpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpd
    iviyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpd
    kwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplte
    eaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarm
    rgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefv
    ntpplvklwyqlekepivgaetf
    

    Sequence, based on observed residues (ATOM records): (download)
    >3drsB (B:)
    ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
    kkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkknksvtvldvgdayfsvpldedf
    rkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqym
    ddlyvgsdleigqhrtkieelrqhllrwgltgyelhpdkwtvqpivlpekdswtvndiqk
    lvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyy
    dpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarhtndvkqlteavqkittesiviw
    gktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq