PDB entry 3dpk

View 3dpk on RCSB PDB site
Description: cFMS tyrosine kinase in complex with a pyridopyrimidinone inhibitor
Class: transferase
Keywords: RECEPTOR TYROSINE KINASE, KINASE-INHIBITOR COMPLEX, ATP-binding, Glycoprotein, Immunoglobulin domain, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Proto-oncogene, Receptor, Transferase, Transmembrane, Tyrosine-protein kinase, Alternative splicing, Chromosomal rearrangement, Craniosynostosis, Disease mutation, Dwarfism, Heparin-binding, Kallmann syndrome
Deposited on 2008-07-08, released 2009-02-17
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-06-30, with a file datestamp of 2009-06-26.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.192
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Macrophage colony-stimulating factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF1R, FMS, FGFR1, FGFBR, FLG, FLT2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3dpka_
  • Heterogens: SO4, 8C5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3dpkA (A:)
    gvdykykqkpkyqvrwkiiesyegnsytfidptqlpynekwefprnnlqfgktlgagafg
    kvveatafglgkedavlkvavkmlkstahadekealmselkimshlgqhenivnllgact
    hggpvlviteyccygdllnflrrkrppgleysynpshnpeeqlssrdllhfssqvaqgma
    flaskncihrdvaarnvlltnghvakigdfglardimndsnyivkgnarlpvkwmapesi
    fdcvytvqsdvwsygillweifslglnpypgilvnskfyklvkdgyqmaqpafapkniys
    imqacwalepthrptfqqicsflqeqaqedrrerd
    

    Sequence, based on observed residues (ATOM records): (download)
    >3dpkA (A:)
    vrwkiiessytfidpynekwefprnnlqfgktlgagafgkvveatafglgavlkvavkml
    kstahadekealmselkimshlgqhenivnllgacthggpvlviteyccygdllnflrrq
    lssrdllhfssqvaqgmaflaskncihrdvaarnvlltnghvakigdfglardimndsny
    ivrlpvkwmapesifdcvytvqsdvwsygillweifslglnpypgilvnskfyklvkdgy
    qmaqpafapkniysimqacwalepthrptfqqicsflqe