PDB entry 3d5s

View 3d5s on RCSB PDB site
Description: Crystal Structure of Efb-C (R131A) / C3d Complex
Class: cell adhesion/toxin
Keywords: Protein-protein complex, cell adhesion/toxin complex, site-directed mutation, Age-related macular degeneration, Cleavage on pair of basic residues, Complement alternate pathway, Complement pathway, Disease mutation, Glycoprotein, Immune response, Inflammatory response, Innate immunity, Phosphoprotein, Polymorphism, Secreted, Thioester bond
Deposited on 2008-05-16, released 2008-09-16
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.204
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Complement C3
    Species: Homo sapiens [TaxId:9606]
    Gene: C3, CPAMD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01024 (5-296)
      • expression tag (0-4)
      • engineered (19)
    Domains in SCOPe 2.05: d3d5sa_
  • Chain 'B':
    Compound: Complement C3
    Species: Homo sapiens [TaxId:9606]
    Gene: C3, CPAMD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01024 (5-296)
      • expression tag (0-4)
      • engineered (19)
    Domains in SCOPe 2.05: d3d5sb_
  • Chain 'C':
    Compound: Fibrinogen-binding protein
    Species: Staphylococcus aureus subsp. aureus str. Newman [TaxId:426430]
    Gene: fib, efb, fib, efb, NWMN_1069
    Database cross-references and differences (RAF-indexed):
    • Uniprot A6QG59 (0-64)
      • engineered (30)
    Domains in SCOPe 2.05: d3d5sc1
  • Chain 'D':
    Compound: Fibrinogen-binding protein
    Species: Staphylococcus aureus subsp. aureus str. Newman [TaxId:426430]
    Gene: fib, efb, fib, efb, NWMN_1069
    Database cross-references and differences (RAF-indexed):
    • Uniprot A6QG59 (0-64)
      • engineered (30)
    Domains in SCOPe 2.05: d3d5sd_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3d5sA (A:)
gsrstdaerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgalelik
kgytqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlile
kqkpdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsit
kagdfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynv
eatsyallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkdap

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3d5sB (B:)
gsrstdaerlkhlivtpsgageqnmigmtptviavhyldeteqwekfglekrqgalelik
kgytqqlafrqpssafaafvkrapstwltayvvkvfslavnliaidsqvlcgavkwlile
kqkpdgvfqedapvihqemigglrnnnekdmaltafvlislqeakdiceeqvnslpgsit
kagdfleanymnlqrsytvaiagyalaqmgrlkgpllnkflttakdknrwedpgkqlynv
eatsyallallqlkdfdfvppvvrwlneqryygggygstqatfmvfqalaqyqkdap

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3d5sC (C:)
tdatikkeqkliqaqnlvrefekthtvsahakaqkavnlvsfeykvkkmvlqeridnvlk
qglvr

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3d5sD (D:)
tdatikkeqkliqaqnlvrefekthtvsahakaqkavnlvsfeykvkkmvlqeridnvlk
qglvr