PDB entry 3d5m

View 3d5m on RCSB PDB site
Description: Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor
Class: transferase
Keywords: protein-ligand complex, RNA polymerase, RNA replication, RNA-binding, transcription, nucleotidyltransferase, hydrolase
Deposited on 2008-05-16, released 2009-05-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-05-19, with a file datestamp of 2009-05-15.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.211
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus (isolate BK) [TaxId:11105]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (0-End)
      • engineered (543)
    Domains in SCOPe 2.08: d3d5ma_
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus (isolate BK) [TaxId:11105]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (0-End)
      • engineered (543)
    Domains in SCOPe 2.08: d3d5mb_
  • Heterogens: 4MS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3d5mA (A:)
    smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
    ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
    svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
    tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
    qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
    aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
    elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
    armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
    einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
    aasqldlsgwfvagysggdiyhslsrarprlehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >3d5mA (A:)
    smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
    ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
    svwkdlledtvtpidttimaknevfcvqpgrkparlivfpdlgvrvcekmalydvvstlp
    qvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqcc
    dlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaac
    raaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydleli
    tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarm
    ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgein
    rvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaas
    qldlsgwfvagysggdiyh
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3d5mB (B:)
    smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
    ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
    svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
    tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
    qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
    aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
    elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
    armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
    einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
    aasqldlsgwfvagysggdiyhslsrarprlehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >3d5mB (B:)
    smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
    ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
    svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
    vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
    apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
    aklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelits
    cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
    mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
    asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasql
    dlsgwfvagysggdiyh